P
P A van der Merwe
Researcher at University of Oxford
Publications - 46
Citations - 5664
P A van der Merwe is an academic researcher from University of Oxford. The author has contributed to research in topics: T-cell receptor & T cell. The author has an hindex of 36, co-authored 46 publications receiving 5452 citations. Previous affiliations of P A van der Merwe include John Radcliffe Hospital & Max Planck Society.
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Journal ArticleDOI
CD80 (B7-1) Binds Both CD28 and CTLA-4 with a Low Affinity and Very Fast Kinetics
TL;DR: In this paper, the authors used surface plasmon resonance to measure the affinity and kinetics of CD80 binding to CD28 and CTLA-4, and showed that these low affinities were the result of very fast dissociation rate constants (k(off)).
Journal ArticleDOI
The kinetic-segregation model: TCR triggering and beyond
Simon J. Davis,P A van der Merwe +1 more
TL;DR: The development of the model is described, new data is reviewed and how the model fits a broader conceptual framework for receptor triggering is suggested, versus that of other proposals, to account for the established features of TCR triggering.
Journal ArticleDOI
The structure and ligand interactions of CD2: implications for T-cell function
Simon J. Davis,P A van der Merwe +1 more
TL;DR: New data on the structure and ligand interactions of the T-cell antigen CD2 are reviewed and their implications for T- cell function in the context of CD2-knockout experiments are considered.
Journal ArticleDOI
Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors.
E J Lepin,J M Bastin,David S.J. Allan,G Roncador,Veronique M. Braud,David Y. Mason,P A van der Merwe,Andrew J. McMichael,John I. Bell,S H Powis,Christopher A. O’Callaghan +10 more
TL;DR: Results suggest that HLA‐F may be a peptide binding molecule and may reach the cell surface under favorable conditions, which may include the presence of specific peptide or peptides.
Journal ArticleDOI
The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation
Corinna McCarthy,Dawn Shepherd,Sebastian J. Fleire,V S Stronge,Michael Koch,Petr A. Illarionov,Giovanna Bossi,Mariolina Salio,Galit Denkberg,Faye Reddington,A Tarlton,B G Reddy,Richard R. Schmidt,Yoram Reiter,Gillian M. Griffiths,P A van der Merwe,Gurdyal S. Besra,E Y Jones,Facundo D. Batista,Vincenzo Cerundolo +19 more
TL;DR: This indirect effect provides a general mechanism by which lipid-specific lymphocytes are capable of recognizing both the group head and the length of lipid antigens, ensuring greater specificity of antigen recognition.