P
P. K. Murthy
Researcher at Central Drug Research Institute
Publications - 74
Citations - 1330
P. K. Murthy is an academic researcher from Central Drug Research Institute. The author has contributed to research in topics: Brugia malayi & Antigen. The author has an hindex of 21, co-authored 73 publications receiving 1254 citations. Previous affiliations of P. K. Murthy include Tulane University.
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Interleukin-10 modulates proinflammatory cytokines in the human monocytic cell line THP-1 stimulated with Borrelia burgdorferi lipoproteins.
TL;DR: The results are consistent with a major role played by IL-10 in controlling the initial phase of infection with this spirochete and reinforces the notion that lipoproteins are the functional molecules in HBb and perhaps in vivo.
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Antifilarial activity in vitro and in vivo of some flavonoids tested against Brugia malayi.
Vijai Lakshmi,Sujith K. Joseph,S. C. Srivastava,Shiv K. Verma,Malaya K. Sahoo,V. Dube,Shikha Mishra,P. K. Murthy +7 more
TL;DR: All 6 flavonoids showed antifilarial activity in vitro, which can be classed, in a decreasing order: naringenin>flavone=hesperetin>rutin>naringin>chrysin, which may provide a lead for design and development of new antIFilarial agent(s).
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Macrofilaricidal activity of the stembark of Streblus asper and its major active constituents
TL;DR: The crude extract of the stembark of Streblus asper, a traditionally used medicinal plant of India, revealed significant macrofilaricidal activity against Litomosoides carinii and Brugia malayi in rodents, opening up the possibility of generating new leads in the development of novel macrofilericides.
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Synthesis of 2-sulfanyl-6-methyl-1,4-dihydropyrimidines as a new class of antifilarial agents.
Brajesh K. Singh,Mridul Mishra,Nisha Saxena,Gaya P. Yadav,Prakas R. Maulik,Malaya K. Sahoo,Rajiv L. Gaur,P. K. Murthy,Rama P. Tripathi +8 more
TL;DR: A series of 2-sulfanyl-6-methyl-1,4-dihydropyrimidines and one of the compounds showed promising antifilarial activity against adult parasites of human lymphatic filarial parasite Brugia malayi in vitro and in vivo at various concentrations.
Journal Article
Antifilarial activity of Caesalpinia bonducella against experimental filarial infections.
Rajiv L. Gaur,Malaya K. Sahoo,Saurabh Dixit,Nigar Fatma,Rastogi S,Kulshreshtha Dk,R. K. Chatterjee,P. K. Murthy +7 more
TL;DR: Assessment of the antifilarial activity of Caesalpinia bonducella-seed kernel against rodent filarial parasite in experimental model indicated the potential of this plant in providing a lead for new antIFilarial drug development.