P
P. Lawlor
Researcher at University of Auckland
Publications - 41
Citations - 5848
P. Lawlor is an academic researcher from University of Auckland. The author has contributed to research in topics: Long-term potentiation & Immediate early gene. The author has an hindex of 32, co-authored 41 publications receiving 5683 citations. Previous affiliations of P. Lawlor include Health Science University.
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Journal ArticleDOI
Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial.
Michael G. Kaplitt,Andrew Feigin,Andrew Feigin,Chengke Tang,Helen L. Fitzsimons,Paul J. Mattis,P. Lawlor,Ross J. Bland,Deborah Young,Kristin Strybing,David Eidelberg,David Eidelberg,Matthew J. During,Matthew J. During +13 more
TL;DR: AAV-GAD gene therapy of the subthalamic nucleus is safe and well tolerated by patients with advanced Parkinson's disease, suggesting that in-vivo gene therapy in the adult brain might be safe for various neurodegenerative diseases.
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Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective.
TL;DR: In addition to its effects on neurogenesis, an enriched environment reduces spontaneous apoptotic cell death in the rat hippocampus by 45%.
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In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes.
Mike Dragunow,Richard L.M. Faull,P. Lawlor,Erica J. Beilharz,K. Singleton,E. B. Walker,Edward W. Mee +6 more
TL;DR: Evidence of DNA fragmentation in cells in temporal cortex and hippocampus from patients with AD and in striatum from those with HD is found, suggesting that apoptosis may be involved in these disorders.
Journal ArticleDOI
Correlations between immediate early gene induction and the persistence of long-term potentiation
Wickliffe C. Abraham,S.E. Mason,Jerome Demmer,Joanna M. Williams,C.L. Richardson,Warren P. Tate,P. Lawlor,Mike Dragunow +7 more
TL;DR: Data provide support for the hypothesis that long-term potentiation 3 involves mechanisms additional to those for long- Term potentiation 2, and one possible mechanism is altered gene expression, initiated by immediate early gene transcription factors such as zif/268 and possibly homo- or heterodimers of Fos and Jun family members, that then contributes to the stabilization or maintenance of long- term potentiation3.
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An oral vaccine against NMDAR1 with efficacy in experimental stroke and epilepsy.
Matthew J. During,Charles W. Symes,P. Lawlor,John Y. Lin,Jane Dunning,Helen L. Fitzsimons,David J. Poulsen,Paola Leone,Ruian Xu,Bridget Dicker,Janusz Lipski,Deborah Young +11 more
TL;DR: A single-dose AAV vaccine was associated with strong anti-epileptic and neuroprotective activity in rats for both a kainate-induced seizure model and also a middle cerebral artery occlusion stroke model at 1 to 5 months following vaccination.