M
Matthew J. During
Researcher at Ohio State University
Publications - 247
Citations - 24557
Matthew J. During is an academic researcher from Ohio State University. The author has contributed to research in topics: Adeno-associated virus & Epilepsy. The author has an hindex of 76, co-authored 246 publications receiving 23100 citations. Previous affiliations of Matthew J. During include University of Auckland & Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain
Michael G. Kaplitt,Paola Leone,Richard Jude Samulski,Xiao Xiao,Donald W. Pfaff,Karen L. O'Malley,Matthew J. During +6 more
TL;DR: It is found that an AAV vector containing the LacZ gene resulted in expression of β-galactosidase up to three months post-injection in vivo, and safe and stable TH gene transfer into the denervated striatum may have potential for the genetic therapy of Parkinson's disease.
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Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial.
Michael G. Kaplitt,Andrew Feigin,Andrew Feigin,Chengke Tang,Helen L. Fitzsimons,Paul J. Mattis,P. Lawlor,Ross J. Bland,Deborah Young,Kristin Strybing,David Eidelberg,David Eidelberg,Matthew J. During,Matthew J. During +13 more
TL;DR: AAV-GAD gene therapy of the subthalamic nucleus is safe and well tolerated by patients with advanced Parkinson's disease, suggesting that in-vivo gene therapy in the adult brain might be safe for various neurodegenerative diseases.
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Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain
TL;DR: Gamma-aminobutyric acid concentrations were unchanged before seizures, but increased during them, with a greater rise in the non-epileptogenic hippocampus, suggesting that a rise in extracellular glutamate may precipitate seizures and that the concentrations reached may cause cell death.
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Glucagon-like peptide-1 receptor is involved in learning and neuroprotection
Matthew J. During,Lei Cao,David S. Zuzga,Jeremy S. Francis,Helen L. Fitzsimons,Xiangyang Jiao,Ross J. Bland,Matthias Klugmann,William A. Banks,Daniel J. Drucker,Colin N. Haile +10 more
TL;DR: Systemic administration of [Ser(2)]exendin(1–9) in wild-type animals prevents kainate-induced apoptosis of hippocampal neurons and represents a promising new target for both cognitive-enhancing and neuroprotective agents.
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Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective.
TL;DR: In addition to its effects on neurogenesis, an enriched environment reduces spontaneous apoptotic cell death in the rat hippocampus by 45%.