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P M Cobden

Researcher at University of Oxford

Publications -  10
Citations -  2166

P M Cobden is an academic researcher from University of Oxford. The author has contributed to research in topics: Hippocampal formation & Intracellular pH. The author has an hindex of 9, co-authored 10 publications receiving 2014 citations.

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Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo

TL;DR: It is reported that three distinct interneuron types—basket, axo-axonic and oriens–lacunosum-moleculare cells—visualized and defined by synaptic connectivity as well as by neurochemical markers, contribute differentially to theta and ripple oscillations in anaesthetized rats.
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Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths.

TL;DR: Diffusion-reaction modeling indicates that CA9 coordinates pHi spatially by facilitating CO2 diffusion in the unstirred extracellular space of the spheroid, suggesting that pHi coordination may favor survival and growth of a tumor.
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Cholecystokinin-immunopositive basket and Schaffer collateral-associated interneurones target different domains of pyramidal cells in the CA1 area of the rat hippocampus.

TL;DR: The division of the postsynaptic neuronal surface by two classes of GABAergic cell expressing cholecystokinin in both the hippocampus and isocortex provides further evidence for the uniform synaptic organisation of the cerebral cortex.
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Immunolocalization of metabotropic glutamate receptor 1alpha (mGluR1alpha) in distinct classes of interneuron in the CA1 region of the rat hippocampus.

TL;DR: The identification of the specific subclasses of CA1 interneurons expressing mGluR1α provides the network basis for assessing the contribution of this receptor to the excitability of the hippocampus.
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Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus.

TL;DR: The postsynaptic interneuron type-specific expression of the high-efficacy presynaptic mGluR8 in both putative glutamatergic and in identified GABAergic terminals predicts a role in adjusting the activity of interneurons depending on the level of network activity.