P
P. N. Lelie
Researcher at University of Amsterdam
Publications - 14
Citations - 1004
P. N. Lelie is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Hepatitis B vaccine & Hepatitis B virus. The author has an hindex of 9, co-authored 14 publications receiving 976 citations.
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Journal ArticleDOI
PREVENTION OF THE HBsAg CARRIER STATE IN NEWBORN INFANTS OF MOTHERS WHO ARE CHRONIC CARRIERS OF HBsAg AND HBeAg BY ADMINISTRATION OF HEPATITIS-B VACCINE AND HEPATITIS-B IMMUNOGLOBULIN: Double-blind Randomised Placebo-controlled study
VivianC.W. Wong,HenriettaM.H. Ip,H. W. Reesink,P. N. Lelie,E. E. Reerink-Brongers,Chap-Yung Yeung,H. K. Ma +6 more
TL;DR: The first set of injections was given within 1 h after birth and 96-100% of the infants in the three treatment groups were anti-HBs positive; the geometric mean titres of antiHBs did not differ significantly as mentioned in this paper.
Journal ArticleDOI
Infectivity of blood seropositive for hepatitis C virus antibodies
C. L. Van Der Poel,Hendrik W. Reesink,W. Schaasberg,Ed Bakker,P.J. Exel-Oehlers,P. N. Lelie,A. Leentvaar-Kuypers +6 more
TL;DR: Use of anti-HCV screening to prevent post-transfusion NANBH was compared with measurement of alanine aminotransferase concentrations: a corrected efficacy of 63% and 65%, a specificity of 93% and 64%, and a positive predictive value of 16.6% were found.
Journal ArticleDOI
Efficacy of heat-inactivated hepatitis B vaccine in haemodialysis patients and staff. Double-blind placebo-controlled trial.
Jan Desmyter,G. De Groote,J. Colaert,M. Reynders,E. E. Reerink-Brongers,P. J. Dees,P. N. Lelie,H. W. Reesink +7 more
TL;DR: The efficacy of a heat-inactivated hepatitis B vaccine, 3 micrograms of surface antigen (HBsAg), given at 0, 1, 2, and 5 months, was evaluated in 401 haemodialysis patients in 18 centers by a placebo-controlled, double-blind, randomised trial as discussed by the authors.
Journal ArticleDOI
Inactivation of 12 viruses by heating steps applied during manufacture of a hepatitis B vaccine
TL;DR: This study shows that the two heat‐inactivation steps used during the production of this vaccine kill a wide variety of viruses that might be present in human blood.
Journal ArticleDOI
Analysis of genomic variability of hepatitis C virus.
H. T. M. Cuypers,I.N. Winkel,C. L. Van Der Poel,H. W. Reesink,P. N. Lelie,Michael Houghton,A J Weiner +6 more
TL;DR: Comparisons of sequences of donors and involved recipients determined in isolates prepared from blood samples four years after transfusion revealed that viral RNA sequences are strongly conserved in the NS3 region, indicating that the observed differences in anti-HCV immune response patterns between recipients are more a reflection of their immune reactivity than of divergence of viral strains.