Journal ArticleDOI
Infectivity of blood seropositive for hepatitis C virus antibodies
C. L. Van Der Poel,Hendrik W. Reesink,W. Schaasberg,Ed Bakker,P.J. Exel-Oehlers,P. N. Lelie,A. Leentvaar-Kuypers +6 more
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TLDR
Use of anti-HCV screening to prevent post-transfusion NANBH was compared with measurement of alanine aminotransferase concentrations: a corrected efficacy of 63% and 65%, a specificity of 93% and 64%, and a positive predictive value of 16.6% were found.About:
This article is published in The Lancet.The article was published on 1990-03-10. It has received 279 citations till now. The article focuses on the topics: Blood product & Hepatitis.read more
Citations
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Journal ArticleDOI
Detection of hepatitis C viral sequences in blood donations by "nested" polymerase chain reaction and prediction of infectivity.
Jeremy A. Garson,Richard S. Tedder,Moya Briggs,Philip W. Tuke,J. A. Glazebrook,A. Trute,D. Parker,J.A.J. Barbara,M. Contreras,S. Aloysius +9 more
TL;DR: Stored serum samples from blood donors who had been involved in three episodes of post-transfusion NANBH in 1981 also contained hepatitis C viral sequences, which seem to be a better predictor of infectivity than the presence of anti-C100 alone.
Journal ArticleDOI
The pathology of hepatitis C.
TL;DR: It is concluded that a characteristic histological pattern exists in chronic hepatitis C, that this pattern is not always found and that prominent lymphoid follicles, though not unique to hepatitisC, provide a useful diagnostic clue.
Journal ArticleDOI
Nucleotide sequence of the genomic RNA of hepatitis C virus isolated from a human carrier: comparison with reported isolates for conserved and divergent regions.
Hiroaki Okamoto,Shunichi Okada,Yasushi Sugiyama,Kiyohiko Kurai,Hisao Iizuka,A Machida,Yuzo Miyakawa,Makoto Mayumi +7 more
TL;DR: The complete nucleotide sequence of a hepatitis C virus derived from plasma of a human carrier in Japan was determined and a high degree of similarity in the amino acid sequence of the putative core protein would make antigen probes deduced from it suitable for the serological diagnosis of HCV infection.
Journal ArticleDOI
Confirmation of hepatitis C virus infection by new four-antigen recombinant immunoblot assay
C. L. Van Der Poel,H. W. Reesink,J. J. P. Van Boven,H. T. M. Cuypers,I.N. Winkel,P.J. Exel-Oehlers,W. Schaasberg,P. N. Lelie,A J Weiner,Alan Polito,Stella Quan,R. Di Nello,Michael Houghton,D. Mulder-Folkerts,A. Leentvaar-Kuypers +14 more
TL;DR: The new 4-RIBA represents a candidate confirmation test to discriminate between infective and non-infective HCV C-100 ELISA-positive blood donors.
Journal ArticleDOI
Sequence variability in the 5' non-coding region of hepatitis C virus: identification of a new virus type and restrictions on sequence diversity.
Peter Simmonds,F. McOmish,P L Yap,Shiu-Wan Chan,C. K. Lin,G. Dusheiko,A A Saeed,Edward C. Holmes +7 more
TL;DR: The specific nucleotide substitutions in the 5' NCR that differentiate each of the four HCV types can be detected by restriction enzyme cleavage, providing a rapid and reliable method for virus typing.
References
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Journal ArticleDOI
An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis
George Kuo,Q L Choo,Harvey J. Alter,G.L. Gitnick,Allan G. Redeker,Robert H. Purcell,Tatsuo Miyamura,Jules L. Dienstag,M.J. Alter,Cladd E. Stevens,Gary E. Tegtmeier,Ferruccio Bonino,Massimo Colombo,W.-S. Lee,C. Kuo,K. Berger,Jeffrey R. Shuster,Lacy Rasco Overby,Daniel W. Bradley,Michael Houghton +19 more
TL;DR: Assays of ten blood transfusions in the United States that resulted in chronic NANBH revealed that there was at least one positive blood donor in nine of these cases and that all ten recipients seroconverted during their illnesses.
Journal ArticleDOI
Hepatitis C virus antibodies among risk groups in Spain.
J.I. Esteban,Luis Viladomiu,Antonio González,Mercè Roget,Joan Genescà,Rafael Esteban,J.C. Lopez-Talavera,José M. de la Torre Hernández,Victor Vargas,Maria Buti,Jaime Guardia,Michael Houghton,Q-L. Choo,George Kuo +13 more
TL;DR: The frequency of hepatitis C virus infection in Spain was assessed by means of a recombinant-based immunoassay for serum anti-HCV antibodies and only 8% of homosexual men infected with human immunodeficiency virus and 6% of female contacts of drug abusers were positive.
Journal ArticleDOI
Detection of hepatitis C viral sequences in non-A, non-B hepatitis.
A J Weiner,G. Kuo,Daniel W. Bradley,Ferruccio Bonino,Giorgio Maria Saracco,C. Lee,Jody Rosenblatt,Qui-Lim Choo,Michael Houghton +8 more
TL;DR: Findings show that anti-C100-3-positive patients with chronic post-transfusion NANBH are likely to be viraemic; confirm that antibodies to C 100-3 are a marker for infectivity; and suggest that the prevalence of HCV infections may be underestimated from the frequency of antibodies to cDNA/polymerase chain reaction alone.
Journal ArticleDOI
Antibody to Hepatitis B Core Antigen as a Paradoxical Marker for Non-A, Non-B Hepatitis Agents in Donated Blood
Deloris E. Koziol,Paul V. Holland,David W. Alling,Jacqueline C. Melpolder,Rachel Solomon,Robert H. Purcell,Lenita M. Hudson,Frances J. Shoup,Henry Krakauer,Harvey J. Alter +9 more
TL;DR: The relationship between the presence of antibody to hepatitis B core antigen (anti-HBc) in donor blood and the development of hepatitis in recipients of that blood was studied and surrogate tests for non-A, non-B virus carriers must be seriously considered.
Journal ArticleDOI
Anti-hepatitis c antibodies and non-a, non-b post-transfusion hepatitis in the netherlands
C. L. Van Der Poel,P. N. Lelie,Q-L. Choo,Hendrik W. Reesink,A.Leent Vaar-Kuypers,George Kuo,Michael Houghton +6 more
TL;DR: Among the donors implicated in transmission of PTH-NANB there was a strong correlation between raised alanine aminotransferase levels and the presence of anti-HCV antibodies.
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An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis
George Kuo,Q L Choo,Harvey J. Alter,G.L. Gitnick,Allan G. Redeker,Robert H. Purcell,Tatsuo Miyamura,Jules L. Dienstag,M.J. Alter,Cladd E. Stevens,Gary E. Tegtmeier,Ferruccio Bonino,Massimo Colombo,W.-S. Lee,C. Kuo,K. Berger,Jeffrey R. Shuster,Lacy Rasco Overby,Daniel W. Bradley,Michael Houghton +19 more