P
Pablo Gastaminza
Researcher at Spanish National Research Council
Publications - 53
Citations - 5568
Pablo Gastaminza is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Hepatitis C virus & Viral replication. The author has an hindex of 22, co-authored 47 publications receiving 5191 citations. Previous affiliations of Pablo Gastaminza include University of Barcelona & Carlos III Health Institute.
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Journal ArticleDOI
Analysis of the interaction of influenza virus polymerase complex with human cell factors.
Núria Jorba,Silvia Juárez,Eva Torreira,Pablo Gastaminza,Pablo Gastaminza,Noelia Zamarreño,Juan Pablo Albar,Juan Ortín +7 more
TL;DR: The interactions recognised in this proteomic approach suggest that the influenza polymerase might be involved in steps of the infection cycle other than RNA replication and transcription.
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Unbiased probing of the entire hepatitis C virus life cycle identifies clinical compounds that target multiple aspects of the infection
TL;DR: An unbiased cell-based screening system involving multiple rounds of infection in a 96-well format is developed, identifying 33 compounds that targeted both known and previously unexplored aspects of HCV infection, including entry, replication, and assembly.
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Long noncoding RNA EGOT negatively affects the antiviral response and favors HCV replication.
Elena Carnero,Marina Barriocanal,Celia Prior,Juan Pablo Unfried,Victor Segura,Elizabeth Guruceaga,Mónica Enguita,Cristian Smerdou,Pablo Gastaminza,Puri Fortes +9 more
TL;DR: The results suggest that EGOT is a lncRNA induced after infection that increases viral replication by antagonizing the antiviral response, providing a novel link between HCV infection and development of liver tumors.
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The Replication Activity of Influenza Virus Polymerase Is Linked to the Capacity of the PA Subunit To Induce Proteolysis
Beatriz Perales,Juan Jose Sanz-Ezquerro,Pablo Gastaminza,Joaquin Ortega,Juan F. Santarén,Juan Ortín,Amelia Nieto +6 more
TL;DR: RNA protection assays of the products obtained with viral polymerase, reconstituted in vivo with model RNAs, indicated that mutations at position 157 led to a selective loss of the ability to synthesize cRNA from the viral RNA template but not to transcribe viral RNA.
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COVID-19 vaccine candidates based on modified vaccinia virus Ankara expressing the SARS-CoV-2 spike induce robust T- and B-cell immune responses and full efficacy in mice.
Juan García-Arriaza,Urtzi Garaigorta,Patricia Pérez,Adrián Lázaro-Frías,Carmen Zamora,Pablo Gastaminza,Carlos del Fresno,José M. Casasnovas,Carlos Oscar S. Sorzano,David Sancho,Mariano Esteban +10 more
TL;DR: In this article, the authors developed two COVID-19 vaccines based on modified vaccinia virus Ankara (MVA) vectors expressing the entire SARS-CoV-2 spike (S) protein, and evaluated their immunogenicity in mice using DNA/MVA or MVA/mVA prime/boost immunization protocols.