Showing papers by "Pamela Ferrari published in 2007"

Diet, serum insulin-like growth factor-I and IGF-binding protein-3 in European women

Abstract: Objective: The aim of this study was to examine the relationship of diet with serum insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 in women. Design: Cross-sectional study. Setting and subjects: The population are 2109 women who were control subjects in a case–control study of breast cancer nested in the European Prospective Investigation into Cancer and Nutrition. Control subjects were randomly chosen among risk sets consisting of female cohort members alive and free of cancer (except non-melanoma skin cancer) at the time of diagnosis of the index case. Matching criteria were age at enrolment, follow-up time, time of the day of blood collection and study centre. Diet was measured through validated questionnaires. Serum hormone concentrations were measured by enzyme-linked immunosorbent assays. The relationship between serum IGF-I, IGFBP-3, and intake of nutrients and foods was explored by linear regression in models adjusted for energy intake, age, body mass index, smoking, physical activity, centre and laboratory batch. Results: Serum IGF-I levels were positively related to protein intake (P trend<0.001), but not related to energy, fat or carbohydrate intake. Positive relationships were observed with the intake of milk (P trend=0.007), calcium (P trend<0.001), magnesium (P trend=0.003), phosphorus (P trend<0.001), potassium (P trend=0.002), vitamin B6 (P trend=0.03), vitamin B2 (P trend=0.001) and inverse relationships with vegetables (P trend=0.02) and beta-carotene (P trend=0.02). IGFBP-3 was not related with most of the nutrients and foods in this study. Conclusions: In this population, circulating IGF-I is modestly related with the intake of protein and minerals, and with milk and cheese, while IGFBP-3 does not appear to be related with diet.

The ATLAS semiconductor tracker end-cap module

Abstract: The challenges for the tracking detector systems at the LHC are unprecedented in terms of the number of channels, the required read-out speed and the expected radiation levels. The ATLAS Semiconductor Tracker. (SCT) end-caps have a total of about 3 million electronics channels each reading out every 25 ns into its own on-chip 3.3 mu s buffer. The highest anticipated dose after 10 years operation is 1.4x10(14) cm(-2) in units of 1 MeV neutron equivalent (assuming the damage factors scale with the non-ionising energy loss). The forward tracker has 1976 double-sided modules, mostly of area similar to 70 cm(2), each having 2 x 768 strips read out by six ASICs per side. The requirement to achieve an average perpendicular radiation length of 1.5% X-0, while coping with up to 7 W dissipation per module (after irradiation), leads to stringent constraints on the thermal design. The additional requirement of 1500e(-) equivalent noise charge (ENC) rising to only 1800e(-) ENC after irradiation, provides stringent design constraints on both the high-density Cu/Polyimide flex read-out circuit and the ABCD3TA read-out ASICs. Finally, the accuracy of module assembly must not compromise the 16 mu m (r phi) resolution perpendicular to the strip directions or 580 mu m radial resolution coming from the 40 mrad front-back stereo angle. A total of 2210 modules were built to the tight tolerances and specifications required for the SCT. This was 234 more than the 1976 required and represents a yield of 93%. The component flow was at times tight, but the module production rate of 40-50 per week was maintained despite this. The distributed production was not found to be a major logistical problem and it allowed additional flexibility to take advantage of where the effort was available, including any spare capacity, for building the end-cap modules. The collaboration that produced the ATLAS SCT end-cap modules kept in close contact at all times so that the effects of shortages or stoppages at different sites could be rapidly resolved.

Serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 concentrations and prostate cancer risk: Results from the European Prospective Investigation into Cancer and Nutrition

Abstract: Background: Some studies suggest that elevated serum insulin-like growth factor (IGF)-I concentrations are associated with an increased risk of prostate cancer and, in particular, with an increased risk of advanced-stage prostate cancer. Methods: We analyzed the association between prediagnostic serum concentrations of IGF-I and IGF-binding protein-3 (IGFBP-3) and prostate cancer risk in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition. This study includes 630 incident prostate cancer cases and 630 matched control subjects. Odds ratios and their 95% confidence intervals (95% CI) were calculated for prostate cancer risk associated with increasing IGF-I and IGFBP-3 concentrations using conditional logistic regression. Results: The risk of total prostate cancer in the highest versus the lowest third of serum peptide concentration was 1.35 (95% CI, 0.99-1.82; P trend = 0.08) for IGF-I, 1.39 (95% CI, 1.02-1.89; P trend = 0.12) for the IGF-I residuals after adjusting for IGFBP-3, 1.22 (95% CI, 0.92-1.64; P trend = 0.38) for IGFBP-3, and 1.01 (95% CI, 0.74-1.37; P trend = 0.75) for the IGFBP-3 residuals after adjusting for IGF-I. There was no significant difference in the association of peptide hormones and prostate cancer by stage of disease, although the association of serum IGF-I concentration with risk was slightly stronger for advanced-stage disease; the odds ratio for the highest versus the lowest third was 1.65 (95% CI, 0.88-3.08; P trend = 0.21) for IGF-I and 1.76 (95% CI, 0.92-3.40; P trend = 0.11) for IGF-I adjusted for IGFBP-3. Conclusions: In this large nested case-control study, serum IGF-I concentration is not strongly associated with prostate cancer risk, although the results are compatible with a small increase in risk, particularly for advanced-stage disease; no association for IGFBP-3 was observed. (Cancer Epidemiol Biomarkers Prev 2007;16(6):1121–7)

Measurement of the e+e- -> W+W- cross section and W decay branching fractions at LEP

Abstract: From a total data sample of 701.1 pb-1 recorded with e+e- centre-of-mass energies of \(\sqrt{s} =\)161–209 GeV with the OPAL detector at LEP, 11693 W-pair candidate events are selected. These data are used to obtain measurements of the W-pair production cross sections at 10 different centre-of-mass energies. The ratio of the measured cross sections to the standard model expectation is found to be: \({\text{data}}/{{\text{SM}}} = 1.002\pm0.011 ({\text{stat.}}) \pm0.007 ({\text{syst.}}) \pm0.005 ({\text{theory}})\), where the uncertainties are statistical, experimental systematics and theory systematics respectively. The data are used to determine the W boson branching fractions, which are found to be consistent with lepton universality of the charged current interaction. Assuming lepton universality, the branching ratio to hadrons is determined to be 67.41±0.37(stat.)±0.23(syst.)%, from which the CKM matrix element |Vcs| is determined to be 0.969±0.017(stat.)±0.012(syst.). The differential cross section as a function of the W- production angle is measured for the qqeν and qqμν final states. The results described in this paper are consistent with the expectations from the standard model.

Bose-Einstein study of position-momentum correlations of charged pions in hadronic Z0 decays

Abstract: A study of Bose–Einstein correlations in pairs of identically charged pions produced in e+e- annihilations at the Z0 peak has been performed for the first time assuming a non-static emitting source. The results are based on the high statistics data obtained with the OPAL detector at LEP. The correlation functions have been analyzed in intervals of the average pair transverse momentum and of the pair rapidity, in order to study possible correlations between the pion production points and their momenta (position–momentum correlations). The Yano–Koonin and the Bertsch–Pratt parameterizations have been fitted to the measured correlation functions to estimate the geometrical parameters of the source as well as the velocity of the source elements with respect to the overall centre-of-mass frame. The source rapidity is found to scale approximately with the pair rapidity, and both the longitudinal and transverse source dimensions are found to decrease for increasing average pair transverse momenta.

Search for invisibly decaying Higgs bosons with large decay width using the OPAL detector at LEP

Abstract: This paper describes a topological search for an invisibly decaying Higgs boson, H, produced via the Bjorken process (e(+)e(-)-> HZ). The analysis is based on data recorded using the OPAL detector at LEP at centre-of-mass energies from 183 to 209 GeV corresponding to a total integrated luminosity of 629 pb(-1). In the analysis only hadronic decays of the Z boson are considered. A scan over Higgs boson masses from 1 to 120 GeV and decay widths from 1 to 3000 GeV revealed no indication for a signal in the data. From a likelihood ratio of expected signal and standard model background we determine upper limits on cross-section times branching ratio to an invisible final state. For moderate Higgs boson decay widths, these range from about 0.07 pb (M-H=60 GeV) to 0.57 pb (M-H=114 GeV). For decay widths above 200 GeV the upper limits are of the order of 0.15 pb. The results can be interpreted in general scenarios predicting a large invisible decay width of the Higgs boson. As an example we interpret the results in the so-called stealthy Higgs scenario. The limits from this analysis exclude a large part of the parameter range of this scenario experimentally accessible at LEP 2.