P
Pamela Vig
Researcher at Imperial College London
Publications - 31
Citations - 1463
Pamela Vig is an academic researcher from Imperial College London. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 10, co-authored 18 publications receiving 1137 citations. Previous affiliations of Pamela Vig include Lincoln's Inn.
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Journal ArticleDOI
A Randomized, Placebo-Controlled Trial of Cenicriviroc for Treatment of Nonalcoholic Steatohepatitis with Fibrosis
Scott L. Friedman,Vlad Ratziu,Stephen A. Harrison,Manal F. Abdelmalek,Guruprasad P. Aithal,Juan Caballería,Sven Francque,Geoffrey C. Farrell,Kris V. Kowdley,Antonio Craxì,Krzysztof Simon,Laurent Fischer,Liza Melchor-Khan,Jeffrey Vest,Brian L. Wiens,Pamela Vig,Star Seyedkazemi,Zachary Goodman,Vincent Wai-Sun Wong,Rohit Loomba,Frank Tacke,Arun J. Sanyal,Eric Lefebvre +22 more
TL;DR: After 1 year of CVC treatment, twice as many subjects achieved improvement in fibrosis and no worsening of SH compared with placebo, and these findings warrant phase 3 evaluation.
Journal ArticleDOI
Hepatic stem cells
TL;DR: Two major aspects of liver stem cell biology are focused on: firstly, the identity of the liver stem cells, and secondly, their potential value in the treatment of major liver disease.
Journal ArticleDOI
Hepatic stem cells: from inside and outside the liver?
Malcolm R. Alison,Pamela Vig,Francesco Paolo Russo,Brian W. Bigger,Eunice Amofah,Michael Themis,Stuart J. Forbes +6 more
TL;DR: A third population of stem cells with hepatic potential resides in the bone marrow; these haematopoietic stem cells may contribute to the albeit low renewal rate of hepatocytes, but can make a more significant contribution to regeneration under a very strong positive selection pressure.
Journal ArticleDOI
The sources of parenchymal regeneration after chronic hepatocellular liver injury in mice.
Pamela Vig,Francesco Paolo Russo,Robert Edwards,Paul J. Tadrous,Nicholas A. Wright,Howard C. Thomas,Malcolm R. Alison,Stuart J. Forbes +7 more
TL;DR: During regenerative stress, the contribution to parenchymal regeneration from the BM is minor and frequently attributable to cell fusion.
Journal ArticleDOI
Pharmacological Inhibition of CCR2/5 Signaling Prevents and Reverses Alcohol-Induced Liver Damage, Steatosis, and Inflammation in Mice
Aditya Ambade,Patrick Lowe,Karen Kodys,Donna Catalano,Benedek Gyongyosi,Yeonhee Cho,Arvin Iracheta-Vellve,Adeyinka Charles Adejumo,Banishree Saha,Charles D. Calenda,Jeeval Mehta,Eric Lefebvre,Pamela Vig,Gyongyi Szabo +13 more
TL;DR: Preclinical evidence for CCR2/CCR5 inhibition with CVC is demonstrated as a potent intervention to ameliorate alcohol‐induced steatohepatitis and liver damage.