P
Panjamurthy Kuppusamy
Researcher at University of Maryland, Baltimore
Publications - 11
Citations - 416
Panjamurthy Kuppusamy is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: MAPK/ERK pathway & Kinase. The author has an hindex of 7, co-authored 10 publications receiving 290 citations.
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ADIPOQ/adiponectin induces cytotoxic autophagy in breast cancer cells through STK11/LKB1-mediated activation of the AMPK-ULK1 axis
Seung J. Chung,Ganji Purnachandra Nagaraju,Arumugam Nagalingam,Nethaji Muniraj,Panjamurthy Kuppusamy,Alyssa Walker,Juhyung Woo,Balázs Győrffy,Ed Gabrielson,Neeraj K. Saxena,Dipali Sharma +10 more
TL;DR: In vitro and in vivo evidence is provided for the integral role of STK11/LKB1-AMPK-ULK1 axis in ADIPOQ/adiponectin-mediated cytotoxic autophagy in breast cancer and for the efficacy of chemotherapeutic agents used in this study.
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Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3
Sonali Sengupta,Arumugam Nagalingam,Nethaji Muniraj,Michael Y. Bonner,Panagiotis Mistriotis,Alexandros Afthinos,Panjamurthy Kuppusamy,Lanoue D,Soonweng Cho,Preethi Korangath,Marey Shriver,Asma Begum,Vanessa F. Merino,Chiung Yu Huang,Jack L. Arbiser,Jack L. Arbiser,William Matsui,Balázs Győrffy,Konstantinos Konstantopoulos,Saraswati Sukumar,Marignani Pa,Neeraj K. Saxena,Dipali Sharma +22 more
TL;DR: The first in vitro and in vivo evidence to support crosstalk between LKB1, Stat3 and pluripotency factors in breast cancer and effective anticancer modulation of this axis with HNK treatment is presented.
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Mechanistic elucidation of the antitumor properties of withaferin a in breast cancer.
TL;DR: WFA treatment inhibited breast tumor formation in xenograft and mouse mammary tumor virus (MMTV)-neu mouse models in a manner associated with activation of the ERK/RSK axis, DR5 upregulation, and elevated nuclear accumulation of Elk1 and CHOP.
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Honokiol abrogates leptin-induced tumor progression by inhibiting Wnt1-MTA1-β-catenin signaling axis in a microRNA-34a dependent manner
Dimiter Avtanski,Arumugam Nagalingam,Panjamurthy Kuppusamy,Michael Y. Bonner,Jack L. Arbiser,Jack L. Arbiser,Neeraj K. Saxena,Dipali Sharma +7 more
TL;DR: First in vitro and in vivo evidence for the leptin-antagonist potential of HNK is provided, revealing a crosstalk between HNK and miR34a and Wnt1-MTA1-β-catenin axis.
Journal ArticleDOI
Benzyl Isothiocyanate potentiates p53 signaling and antitumor effects against breast cancer through activation of p53-LKB1 and p73-LKB1 axes.
Bei Xie,Arumugam Nagalingam,Panjamurthy Kuppusamy,Nethaji Muniraj,Peter Langford,Balázs Győrffy,Neeraj K. Saxena,Dipali Sharma +7 more
TL;DR: First in vitro and in vivo evidence of the integral role of previously unrecognized crosstalk between BITC, p53/L KB1 and p73/LKB1 axes in breast tumor growth-inhibition is provided.