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Paola Sacchetti
Researcher at University of Hartford
Publications - 21
Citations - 1878
Paola Sacchetti is an academic researcher from University of Hartford. The author has contributed to research in topics: Transcriptional regulation & Dopamine transporter. The author has an hindex of 16, co-authored 20 publications receiving 1710 citations. Previous affiliations of Paola Sacchetti include Wayne State University & French Institute of Health and Medical Research.
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Journal ArticleDOI
Candida albicans Phospholipomannan Is Sensed through Toll-Like Receptors
Thierry Jouault,Stella Ibata-Ombetta,Osamu Takeuchi,Pierre-André Trinel,Paola Sacchetti,Philippe Lefebvre,Shizuo Akira,Daniel Poulain +7 more
TL;DR: Candida albicans is a common, harmless yeast in the human digestive tract that also causes severe systemic fungal infection in hospitalized patients, and the ability of PLM to stimulate tumor necrosis factor (TNF)-alpha production by J774 mouse cells correlates with the activation of nuclear factor (NF)-kappaB.
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Nurr1 enhances transcription of the human dopamine transporter gene through a novel mechanism.
TL;DR: Functional analysis of a series of gene constructs revealed that a region of the hDAT 5′‐flanking sequence devoid of NGFI‐B response element (NBRE)‐like sites mediated nurr1 activation, suggesting that nurR1 activates hDat transcription via a novel NBRE‐independent mechanism.
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The human dopamine transporter gene: gene organization, transcriptional regulation, and potential involvement in neuropsychiatric disorders.
TL;DR: The cloning and organization of the human dopamine transporter gene, polymorphisms in its coding and noncoding sequence, and emerging data on its transcriptional regulation are reviewed.
Journal ArticleDOI
Characterization of the 5'-flanking region of the human dopamine transporter gene.
Paola Sacchetti,Lisa A. Brownschidle,James G. Granneman,James G. Granneman,Michael J. Bannon +4 more
TL;DR: The results suggest that the proximal hDAT 5'-flanking region displays a strong, nonselective promoter activity that is silenced through regulatory elements present in the distal portion of the 5-flanking sequence.
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1,25-dihydroxyvitamin D3 protects RINm5F and human islet cells against cytokine-induced apoptosis: implication of the antiapoptotic protein A20.
Rita Riachy,Brigitte Vandewalle,Julie Kerr Conte,Ericka Moerman,Paola Sacchetti,Bruno Lukowiak,Valery Gmyr,Thomas Bouckenooghe,Mathilde Dubois,François Pattou +9 more
TL;DR: A clear efficiency of 1,25-(OH)2D3 on the apoptotic machinery triggered by cytokines in beta-cells is shown and suggests that 1, 25-(OH), 2D3 could help overcome a major obstacle encountered in the cellular therapy of diabetes, such as nonfunction in the immediate posttransplantation period.