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Paola Scaruffi
Researcher at National Cancer Research Institute
Publications - 89
Citations - 2135
Paola Scaruffi is an academic researcher from National Cancer Research Institute. The author has contributed to research in topics: Neuroblastoma & Gene. The author has an hindex of 26, co-authored 78 publications receiving 1838 citations. Previous affiliations of Paola Scaruffi include Boston Children's Hospital.
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Journal ArticleDOI
Prognostic Impact of Gene Expression–Based Classification for Neuroblastoma
André Oberthuer,Barbara Hero,Frank Berthold,Dilafruz Juraeva,Andreas Faldum,Yvonne Kahlert,Shahab Asgharzadeh,Robert C. Seeger,Paola Scaruffi,Gian Paolo Tonini,Isabelle Janoueix-Lerosey,Olivier Delattre,Gudrun Schleiermacher,Jo Vandesompele,Joëlle Vermeulen,Franki Speleman,Rosa Noguera,Marta Piqueras,Jean Bénard,Alexander Valent,Smadar Avigad,Isaac Yaniv,Axel Weber,Holger Christiansen,Richard Grundy,Katharina Schardt,Manfred Schwab,Roland Eils,Patrick Warnat,Lars Kaderali,Thorsten Simon,Boris Decarolis,Jessica Theissen,Frank Westermann,Benedikt Brors,Matthias Fischer +35 more
TL;DR: Gene expression-based classification using the 144-gene PAM predictor can contribute to improved treatment stratification of neuroblastoma patients.
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Mitochondrial DNA content in embryo culture medium is significantly associated with human embryo fragmentation
TL;DR: The correlation between a high mtDNA concentration and the fragmentation rate of embryos is suggestive that fragments are mainly anuclear cytoplasmatic debris arising during cleavage, which may play a homeostatic role and be related to embryo competence.
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MYCN oncogene amplification in neuroblastoma is associated with worse prognosis, except in stage 4s: the Italian experience with 295 children.
Gian Paolo Tonini,L Boni,Andrea Pession,D Rogers,A Iolascon,Giuseppe Basso,L Cordero di Montezemolo,Fiorina Casale,Patrizia Perri,Katia Mazzocco,Paola Scaruffi,C Lo Cunsolo,Nora Marchese,Claudia Milanaccio,Massimo Conte,Paolo Bruzzi,B. De Bernardi +16 more
TL;DR: MyCN amplification is associated with a worse prognosis in children with neuroblastoma at all ages and stages except 4s, and this association is most pronounced inChildren with otherwise favorable prognostic indicators, and in these children should be considered as an indication for more intensive intervention.
Journal ArticleDOI
Transcribed-Ultra Conserved Region expression is associated with outcome in high-risk neuroblastoma.
Paola Scaruffi,Sara Stigliani,Stefano Moretti,Simona Coco,Carla De Vecchi,Francesca Valdora,Alberto Garaventa,Stefano Bonassi,Gian Paolo Tonini +8 more
TL;DR: A deregulation of the microRNA/T-UCR network may play an important role in the pathogenesis of neuroblastoma, and findings may be applied as the first T-U CR prognostic signature for high-risk neuroblastomas patients.
Journal ArticleDOI
Impact of infertility and infertility treatments on quality of life and levels of anxiety and depression in women undergoing in vitro fertilization.
Claudia Massarotti,Giulia Gentile,Chiara Ferreccio,Paola Scaruffi,Valentino Remorgida,Paola Anserini +5 more
TL;DR: Levels of anxiety and depression in women, correlated with infertility per se and with infertility treatments, are evaluated, highlighting predictors of higher levels of distress and to help the treating physician to better counsel patients and to provide a more focused psychological support.