H
Holger Christiansen
Researcher at Leipzig University
Publications - 95
Citations - 4559
Holger Christiansen is an academic researcher from Leipzig University. The author has contributed to research in topics: Neuroblastoma & Cancer. The author has an hindex of 33, co-authored 90 publications receiving 4272 citations. Previous affiliations of Holger Christiansen include Boston Children's Hospital & University of Marburg.
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Journal ArticleDOI
Gain of chromosome arm 17q and adverse outcome in patients with neuroblastoma
Nick Bown,Simon Cotterill,Maria Lastowska,Seamus O'Neill,Adj Pearson,Dominique Plantaz,M Meddeb,Gisèle Danglot,C. Brinkschmidt,Holger Christiansen,Genevieve Laureys,Franki Speleman,J.C. Nicholson,Alain Bernheim,David R Betts,Jo Vandesompele,N. Van Roy +16 more
TL;DR: Gain of chromosome segment 17q21-qter is an important prognostic factor in children with neuroblastoma and was a significant predictive factor for adverse outcome in univariate analysis and in multivariate analysis.
Journal ArticleDOI
Stabilization of N-Myc Is a Critical Function of Aurora A in Human Neuroblastoma
Tobias Otto,Sebastian Horn,Markus Brockmann,Ursula Eilers,Lars Schüttrumpf,Nikita Popov,Anna Marie Kenney,Johannes H. Schulte,Roderick L. Beijersbergen,Holger Christiansen,Bernd Berwanger,Martin Eilers +11 more
TL;DR: AURKA is identified as a gene that is required for the growth of MYCN-amplified neuroblastoma cells but largely dispensable for cells lacking amplified MYCN, and Aurora A has a critical function in regulating turnover of the N-Myc protein.
Journal ArticleDOI
Does expression of different EWS chimeric transcripts define clinically distinct risk groups of Ewing tumor Patients
Andreas Zoubek,Barbara Dockhorn-Dworniczak,Olivier Delattre,Holger Christiansen,Felix Niggli,I Gatterer-Menz,T L Smith,Heribert Jürgens,Helmut Gadner,Heinrich Kovar +9 more
TL;DR: Results suggest a possible advantage in PFS for patients with localized disease and fusion type I transcripts, although this will require prospective validation with a larger number of patients and longer follow-up periods.
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MYCN regulates oncogenic MicroRNAs in neuroblastoma.
Johannes H. Schulte,Sebastian Horn,Tobias Otto,Birgit Samans,Lukas C. Heukamp,Ursula-Christa Eilers,Michael Krause,Kathy Astrahantseff,Ludger Klein-Hitpass,Reinhard Buettner,Alexander Schramm,Holger Christiansen,Martin Eilers,Angelika Eggert,Bernd Berwanger +14 more
TL;DR: It is shown here that miR‐221 is also induced by MYCN in neuroblastoma, and miRNA induction is reported to be a new mechanism of gene expression downregulation by Myc.
Journal Article
N-myc Regulates Oncogenic microRNAs in neuroblastoma
Johannes H. Schulte,Sebastian Horn,Birgit Samans,Lukas C. Heukamp,Ursula-Christa Eilers,Tobias Otto,Michael Krause,Kathy Astrahantseff,Reinhard Buettner,Alexander Schramm,Holger Christiansen,Martin Eilers,Angelika Eggert,Bernd Berwanger +13 more
TL;DR: In this article, the role of Nmyc in regulation of miRNA expression was analyzed and shown to be positively correlated with MYCN amplification in 28 primary neuroblastoma patients.