Paola Sebastiani

TL;DR: Findings indicate that gene expression in cytologically normal large-airway epithelial cells can serve as a lung cancer biomarker, potentially owing to a cancer-specific airway-wide response to cigarette smoke.

TL;DR: The method represents gene-expression dynamics as autoregressive equations and uses an agglomerative procedure to search for the most probable set of clusters given the available data and acquires an independent, principled measure to decide when two series are different enough to belong to different clusters.

TL;DR: In-silico analysis suggests that 90% of centenarians can be grouped into clusters characterized by different “genetic signatures” of varying predictive values for exceptional longevity.

TL;DR: New efforts to induce high HbF levels in sickle cell disease beyond those achievable with the current limited repertory of Hbf inducers are spurred on.

TL;DR: Syndromic surveillance refers to methods relying on detection of individual and population health indicators that are discernible before confirmed diagnoses are made as discussed by the authors, in particular, before the laboratory confirmation of an infectious disease, ill persons may exhibit behavioral patterns, symptoms, signs, or laboratory findings that can be tracked through a variety of data sources.