K
Kyle M. Walsh
Researcher at Duke University
Publications - 138
Citations - 7873
Kyle M. Walsh is an academic researcher from Duke University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 32, co-authored 118 publications receiving 5930 citations. Previous affiliations of Kyle M. Walsh include University of California, San Francisco & Yale University.
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Journal ArticleDOI
The epidemiology of glioma in adults: a "state of the science" review.
Quinn T. Ostrom,Luc Bauchet,Faith G. Davis,Isabelle Deltour,James L. Fisher,Chelsea Eastman Langer,Melike Pekmezci,Judith A. Schwartzbaum,Michelle C. Turner,Kyle M. Walsh,Margaret Wrensch,Jill S. Barnholtz-Sloan +11 more
TL;DR: A “state of the science” review of current research into causes and risk factors for gliomas in adults is provided.
Journal ArticleDOI
Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors
Jeanette E. Eckel-Passow,Daniel H. Lachance,Annette M. Molinaro,Kyle M. Walsh,Paul A. Decker,Hugues Sicotte,Melike Pekmezci,Terri Rice,Matt L. Kosel,Ivan Smirnov,Gobinda Sarkar,Alissa Caron,Thomas M. Kollmeyer,Corinne Praska,Anisha R. Chada,Chandralekha Halder,Helen M. Hansen,Lucie McCoy,Paige M. Bracci,Roxanne Marshall,Shichun Zheng,Gerald F. Reis,Alexander R. Pico,Brian P. O'Neill,Jan C. Buckner,Caterina Giannini,Jason T. Huse,Arie Perry,Tarik Tihan,Mitchell S. Berger,Susan M. Chang,Michael D. Prados,Joseph L. Wiemels,John K. Wiencke,Margaret Wrensch,Robert B. Jenkins +35 more
TL;DR: The five glioma molecular groups had different ages at onset, overall survival, and associations with germline variants, which implies that they are characterized by distinct mechanisms of pathogenesis.
Journal ArticleDOI
The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer
Robert J.A. Bell,H. Tomas Rube,Alex Kreig,Andrew Mancini,Shaun D. Fouse,Raman P. Nagarajan,Serah Choi,Chibo Hong,Daniel He,Melike Pekmezci,John K. Wiencke,Margaret Wrensch,Susan M. Chang,Kyle M. Walsh,Sua Myong,Jun S. Song,Joseph F. Costello +16 more
TL;DR: Cancer-associated mutations in the promoter of the telomerase gene allow increased activation by transcription factor binding, and GABP thus directly links TERT promoter mutations to aberrant expression in multiple cancers.
Journal ArticleDOI
Genetic signatures of exceptional longevity in humans.
Paola Sebastiani,Nadia Solovieff,Andrew T. DeWan,Kyle M. Walsh,Annibale Alessandro Puca,Stephen W. Hartley,Efthymia Melista,Stacy L. Andersen,Daniel A. Dworkis,Jemma B. Wilk,Richard H. Myers,Martin H. Steinberg,Monty Montano,Clinton T. Baldwin,Josephine Hoh,Thomas T. Perls +15 more
TL;DR: In-silico analysis suggests that 90% of centenarians can be grouped into clusters characterized by different “genetic signatures” of varying predictive values for exceptional longevity.
Journal ArticleDOI
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study
Philip C Haycock,Stephen Burgess,Aayah Nounu,Jie Zheng,G N Okoli,Jack Bowden,Kaitlin H Wade,Nicholas J. Timpson,David M. Evans,Peter Willeit,Abraham Aviv,Tom R. Gaunt,Gibran Hemani,Massimo Mangino,Hayley P Ellis,Kathreena M Kurian,Karen A. Pooley,Rosalind A. Eeles,Jeffrey E. Lee,Shenying Fang,Wei V. Chen,Matthew Law,Lisa Bowdler,Mark M. Iles,Qiong Yang,Bradford B. Worrall,Hugh S. Markus,Rayjean J. Hung,Christopher I. Amos,Amanda B. Spurdle,Deborah J. Thompson,Tracy A. O'Mara,Brian M. Wolpin,Laufey T. Amundadottir,Rachael Z. Stolzenberg-Solomon,Antonia Trichopoulou,N. Charlotte Onland-Moret,Eiliv Lund,Eric J. Duell,Federico Canzian,Gianluca Severi,Kim Overvad,Marc J. Gunter,Rosario Tumino,Ulrika Svenson,Andre M. van Rij,Annette F. Baas,Matthew J. Bown,Nilesh J. Samani,Femke N G van t'Hof,Gerard Tromp,Gregory T. Jones,Helena Kuivaniemi,James R. Elmore,Mattias Johansson,James McKay,Ghislaine Scelo,Robert Carreras-Torres,Valerie Gaborieau,Paul Brennan,Paige M. Bracci,Rachel E. Neale,Sara H. Olson,Steven Gallinger,Donghui Li,Gloria M. Petersen,Harvey A. Risch,Alison P. Klein,Jiali Han,Christian C. Abnet,Neal D. Freedman,Philip R. Taylor,John M. Maris,Katja K.H. Aben,Lambertus A. Kiemeney,Sita H. Vermeulen,John K. Wiencke,Kyle M. Walsh,Margaret Wrensch,Terri Rice,Clare Turnbull,Kevin Litchfield,Lavinia Paternoster,Marie Standl,Gonçalo R. Abecasis,John Paul SanGiovanni,Yong Li,Vladan Mijatovic,Yadav Sapkota,Siew-Kee Low,Krina T. Zondervan,Grant W. Montgomery,Dale R. Nyholt,David A. van Heel,Karen A. Hunt,Dan E. Arking,Foram N. Ashar,Nona Sotoodehnia,Daniel Woo,Jonathan Rosand,Mary E. Comeau,W. Mark Brown,Edwin K. Silverman,John E. Hokanson,Michael H. Cho,Jennie Hui,Manuel A. R. Ferreira,Philip J. Thompson,Alanna C. Morrison,Janine F. Felix,Nicholas L. Smith,Angela M. Christiano,Lynn Petukhova,Regina C. Betz,Xing Fan,Xuejun Zhang,Caihong Zhu,Carl D. Langefeld,Susan D. Thompson,Feijie Wang,Xu Lin,David A. Schwartz,Tasha E. Fingerlin,Jerome I. Rotter,Mary Frances Cotch,Richard A. Jensen,Matthias Munz,Henrik Dommisch,Arne S. Schaefer,Fang Han,Hanna Ollila,Ryan P. Hillary,Omar M. E. Albagha,Stuart H. Ralston,Chenjie Zeng,Wei Zheng,Xiao-Ou Shu,André Reis,Steffen Uebe,Ulrike Hüffmeier,Yoshiya Kawamura,Takeshi Otowa,Tsukasa Sasaki,Martin L. Hibberd,Sonia Davila,Gang Xie,Katherine A. Siminovitch,Jin-Xin Bei,Yi Xin Zeng,Asta Försti,Bowang Chen,Stefano Landi,Andre Franke,Annegret Fischer,David Ellinghaus,Carlos Flores,Imre Noth,Shwu-Fan Ma,Jia Nee Foo,Jianjun Liu,Jong-Won Kim,David G. Cox,Olivier Delattre,Olivier Mirabeau,Christine F. Skibola,Clara S. Tang,Merce Garcia-Barcelo,Kai-Ping Chang,Wen-Hui Su,Yu-Sun Chang,Nicholas G. Martin,Scott D. Gordon,Tracey D. Wade,Chaeyoung Lee,Michiaki Kubo,Pei-Chieng Cha,Yusuke Nakamura,Daniel Levy,Masayuki Kimura,Shih-Jen Hwang,Steven C. Hunt,Tim D. Spector,Nicole Soranzo,Ani Manichaikul,R. Graham Barr,Bratati Kahali,Elizabeth K. Speliotes,Laura M. Yerges-Armstrong,Ching-Yu Cheng,Jost B. Jonas,Tien Yin Wong,Isabella Fogh,Kuang Lin,John Powell,Kenneth Rice,Caroline L Relton,Richard M. Martin,George Davey Smith +197 more
TL;DR: It is likely that longer telomeres increase risk for several cancers but reduce risk for some non-neoplastic diseases, including cardiovascular diseases, as well as single nucleotide polymorphisms (SNPs) that are strongly associated with telomere length in the general population.