P
Paolo C. Colombo
Researcher at Columbia University
Publications - 345
Citations - 10491
Paolo C. Colombo is an academic researcher from Columbia University. The author has contributed to research in topics: Ventricular assist device & Heart failure. The author has an hindex of 48, co-authored 345 publications receiving 8339 citations. Previous affiliations of Paolo C. Colombo include NewYork–Presbyterian Hospital & Columbia University Medical Center.
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Journal ArticleDOI
A Fully Magnetically Levitated Circulatory Pump for Advanced Heart Failure
Mandeep R. Mehra,Yoshifumi Naka,Nir Uriel,Daniel J. Goldstein,Joseph C. Cleveland,Paolo C. Colombo,Mary Norine Walsh,Carmelo A. Milano,Chetan B. Patel,Ulrich P. Jorde,Francis D. Pagani,Keith D. Aaronson,David A. Dean,Kelly McCants,Akinobu Itoh,Gregory A. Ewald,Douglas A. Horstmanshof,James W. Long,Christopher T. Salerno +18 more
TL;DR: Among patients with advanced heart failure, implantation of a fully magnetically levitated centrifugal‐flow pump was associated with better outcomes at 6 months than was implanted of an axial‐ flow pump, primarily because of the lower rate of reoperation for pump malfunction.
Journal ArticleDOI
Inflammation, Oxidative Stress, and Repair Capacity of the Vascular Endothelium in Obstructive Sleep Apnea
Sanja Jelic,Margherita Padeletti,Steven M. Kawut,Chris Higgins,Stephen M. Canfield,Duygu Onat,Paolo C. Colombo,Robert C. Basner,Phillip Factor,Thierry H. LeJemtel +9 more
TL;DR: OSA directly affects the vascular endothelium by promoting inflammation and oxidative stress while decreasing NO availability and repair capacity and effective CPAP therapy is associated with the reversal of these alterations.
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Development of a novel echocardiography ramp test for speed optimization and diagnosis of device thrombosis in continuous-flow left ventricular assist devices: the Columbia ramp study.
Nir Uriel,Kerry A. Morrison,Arthur R. Garan,Tomoko S. Kato,Melana Yuzefpolskaya,Farhana Latif,Susan Restaino,Donna Mancini,M. Flannery,Hiroo Takayama,Ranjit John,Paolo C. Colombo,Yoshifumi Naka,Ulrich P. Jorde +13 more
TL;DR: A unique ramp test protocol to be routinely used at the time of discharge for speed optimization and/or if device malfunction was suspected and may be used to monitor the effects of therapeutic interventions and need for surgical intervention in CF-LVAD patients.
Journal ArticleDOI
Alloantigen specific CD8+CD28- FOXP3+ T suppressor cells induce ILT3+ ILT4+ tolerogenic endothelial cells, inhibiting alloreactivity.
John S. Manavalan,Seunghee Kim-Schulze,Luigi Scotto,Afzal J. Naiyer,George Vlad,Paolo C. Colombo,Charles C. Marboe,Donna Mancini,Raffaello Cortesini,Nicole Suciu-Foca +9 more
TL;DR: Using RT-PCR, it is shown that alloantigen specific CD8(+)CD28(-) T suppressor cells generated in vitro are FOXP3 positive and interact with human endothelial cells, which results in the induction of inhibitory receptors and down-regulation of costimulatory and adhesion molecules, thus rendering endothelial Cells tolerogenic.
Journal ArticleDOI
Prevalence of de novo aortic insufficiency during long-term support with left ventricular assist devices
Sang Woo Pak,Nir Uriel,Hiroo Takayama,Sarah Cappleman,Robert Song,Paolo C. Colombo,Sandy Charles,Donna Mancini,Linda D. Gillam,Yoshifumi Naka,Ulrich P. Jorde +10 more
TL;DR: Aortic insufficiency occurs frequently in patients who receive continuous-flow support with a HMII LVAD, and may be associated with aortic root diameter enlargement and aortsic valve opening.