Luigi Scotto

TL;DR: The findings implicate a role for these genes in CC tumorigenesis, represent an important step toward the development of clinically significant biomarkers, and form a framework for testing as molecular therapeutic targets.

TL;DR: Using RT-PCR, it is shown that alloantigen specific CD8(+)CD28(-) T suppressor cells generated in vitro are FOXP3 positive and interact with human endothelial cells, which results in the induction of inhibitory receptors and down-regulation of costimulatory and adhesion molecules, thus rendering endothelial Cells tolerogenic.

TL;DR: Assessing the effect of rapamycin on the growth of nonregulatory and Treg populations of defined differentiation stages purified ex vivo from circulating CD4+ T cells shows that this phenomenon is not due to a selective expansion of naturally occurring Tregs, but to the capacity ofRapamycin to induce, upon TCR-mediated stimulation, suppressor functions in conventional CD4- T cells.

TL;DR: It is suggested that whereas one mechanism of EGF receptor recruitment into coated pits involves high-affinity binding of AP-2 to Tyr974-containing motif, another pathway may be mediated by weak receptor/AP-2 interactions or by proteins other than AP- 2.

TL;DR: In multiple myeloma, Fbxw7α and GSK3 function as pro-survival factors through the control of p100 degradation, a member of the F-box family of proteins, which function as the substrate-targeting subunits of SCF (Skp1/Cul1/F-box protein) ubiquitin ligase complexes.