There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.

Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

I and i

다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

On August 17, 2017 at 12∶41:04 UTC the Advanced LIGO and Advanced Virgo gravitational-wave detectors made their first observation of a binary neutron star inspiral. The signal, GW170817, was detected with a combined signal-to-noise ratio of 32.4 and a false-alarm-rate estimate of less than one per 8.0×10^{4}  years. We infer the component masses of the binary to be between 0.86 and 2.26  M_{⊙}, in agreement with masses of known neutron stars. Restricting the component spins to the range inferred in binary neutron stars, we find the component masses to be in the range 1.17-1.60  M_{⊙}, with the total mass of the system 2.74_{-0.01}^{+0.04}M_{⊙}. The source was localized within a sky region of 28  deg^{2} (90% probability) and had a luminosity distance of 40_{-14}^{+8}  Mpc, the closest and most precisely localized gravitational-wave signal yet. The association with the γ-ray burst GRB 170817A, detected by Fermi-GBM 1.7 s after the coalescence, corroborates the hypothesis of a neutron star merger and provides the first direct evidence of a link between these mergers and short γ-ray bursts. Subsequent identification of transient counterparts across the electromagnetic spectrum in the same location further supports the interpretation of this event as a neutron star merger. This unprecedented joint gravitational and electromagnetic observation provides insight into astrophysics, dense matter, gravitation, and cosmology.

/pdf/gw170817-observation-of-gravitational-waves-from-a-binary-q2x9byg981.pdf

GW170817: observation of gravitational waves from a binary neutron star inspiral

Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis

We study Einstein-Maxwell-dilaton gravity models in four-dimensional antide Sitter (AdS) spacetime which admit the Reissner-Nordstrom (RN) black hole solution. We show that below a critical temperature the AdS-RN solution becomes unstable against scalar perturbations and the gravitational system undergoes a phase transition. We show using numerical calculations that the new phase is a charged dilatonic black hole. Using the AdS/CFT correspondence we discuss the phase transition in the dual field theory both for non-vanishing temperatures and in the extremal limit. The extremal solution has a Lifshitz scaling symmetry. We discuss the optical conductivity in the new dual phase and find interesting behavior at low frequencies where it shows a “Drude peak”. The resistivity varies with temperature in a non-monotonic way and displays a minimum at low temperatures which is reminiscent of the celebrated Kondo effect.

Phase transitions between Reissner-Nordstrom and dilatonic black holes in 4D AdS spacetime

Black-hole perturbation theory is a useful tool to investigate issues in astrophysics, high-energy physics, and fundamental problems in gravity. It is often complementary to fully-fledged nonlinear evolutions and instrumental to interpret some results of numerical simulations. Several modern applications require advanced tools to investigate the linear dynamics of generic small perturbations around stationary black holes. Here, we present an overview of these applications and introduce extensions of the standard semianalytical methods to construct and solve the linearized field equations in curved space–time. Current state-of-the-art techniques are pedagogically explained and exciting open problems are presented.

Advanced methods in black-hole perturbation theory

Ultralight bosons and axion-like particles appear naturally in different scenarios and could solve some long-standing puzzles. Their detection is challenging, and all direct methods hinge on unknown couplings to the Standard Model of particle physics. However, the universal coupling to gravity provides model-independent signatures for these fields. We explore here the superradiant instability of spinning black holes triggered in the presence of such fields. The instability taps angular momentum from and limits the maximum spin of astrophysical black holes. We compute, for the first time, the spectrum of the most unstable modes of a massive vector (Proca) field for generic black-hole spin and Proca mass. The observed stability of the inner disk of stellar-mass black holes can be used to derive \emph{direct} constraints on the mass of dark photons in the mass range $ 10^{-13}\,{\rm eV}\lesssim m_V \lesssim 3\times 10^{-12}\,{\rm eV}$. By including also higher azimuthal modes, similar constraints apply to axion-like particles in the mass range $6\times10^{-13}\,{\rm eV}\lesssim m_{\rm ALP} \lesssim 10^{-11}\, {\rm eV}$. Likewise, mass and spin distributions of supermassive BHs --~as measured through continuum fitting, K$\alpha$ iron line, or with the future space-based gravitational-wave detector LISA~-- imply indirect bounds in the mass range approximately $10^{-19}\,{\rm eV}\lesssim m_V, m_{\rm ALP} \lesssim 10^{-13}\, {\rm eV}$, for both axion-like particles and dark photons. Overall, superradiance allows to explore a region of approximately $8$ orders of magnitude in the mass of ultralight bosons.

/pdf/constraining-the-mass-of-dark-photons-and-axion-like-5fnf176olg.pdf

Constraining the mass of dark photons and axion-like particles through black-hole superradiance

/pdf/gravitational-wave-searches-for-ultralight-bosons-with-ligo-3vq5u2s1gr.pdf

Gravitational wave searches for ultralight bosons with LIGO and LISA

Primordial black holes (PBHs) might be formed in the early Universe and could comprise at least a fraction of the dark matter. Using the recently released GWTC-2 dataset from the third observing run of the LIGO-Virgo Collaboration, we investigate whether current observations are compatible with the hypothesis that all black hole mergers detected so far are of primordial origin. We constrain PBH formation models within a hierarchical Bayesian inference framework based on deep learning techniques, finding best-fit values for distinctive features of these models, including the PBH initial mass function, the fraction of PBHs in dark matter, and the accretion efficiency. The presence of several spinning binaries in the GWTC-2 dataset favors a scenario in which PBHs accrete and spin up. Our results indicate that PBHs may comprise only a fraction smaller than 0.3% of the total dark matter, and that the predicted PBH abundance is still compatible with other constraints.

Paolo Pani

Papers

Phase transitions between Reissner-Nordstrom and dilatonic black holes in 4D AdS spacetime

Advanced methods in black-hole perturbation theory

Constraining the mass of dark photons and axion-like particles through black-hole superradiance

Gravitational wave searches for ultralight bosons with LIGO and LISA

Constraining the primordial black hole scenario with Bayesian inference and machine learning: The GWTC-2 gravitational wave catalog