There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.

Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

I and i

다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

On August 17, 2017 at 12∶41:04 UTC the Advanced LIGO and Advanced Virgo gravitational-wave detectors made their first observation of a binary neutron star inspiral. The signal, GW170817, was detected with a combined signal-to-noise ratio of 32.4 and a false-alarm-rate estimate of less than one per 8.0×10^{4}  years. We infer the component masses of the binary to be between 0.86 and 2.26  M_{⊙}, in agreement with masses of known neutron stars. Restricting the component spins to the range inferred in binary neutron stars, we find the component masses to be in the range 1.17-1.60  M_{⊙}, with the total mass of the system 2.74_{-0.01}^{+0.04}M_{⊙}. The source was localized within a sky region of 28  deg^{2} (90% probability) and had a luminosity distance of 40_{-14}^{+8}  Mpc, the closest and most precisely localized gravitational-wave signal yet. The association with the γ-ray burst GRB 170817A, detected by Fermi-GBM 1.7 s after the coalescence, corroborates the hypothesis of a neutron star merger and provides the first direct evidence of a link between these mergers and short γ-ray bursts. Subsequent identification of transient counterparts across the electromagnetic spectrum in the same location further supports the interpretation of this event as a neutron star merger. This unprecedented joint gravitational and electromagnetic observation provides insight into astrophysics, dense matter, gravitation, and cosmology.

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GW170817: observation of gravitational waves from a binary neutron star inspiral

Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis

Hexose monophosphate shunt and cholesterol synthesis in the diabetic and fasting states.

In a close encounter with a neutron star, a primordial black hole can get gravitationally captured by depositing a considerable amount of energy into nonradial stellar modes of very high angular number $l$. If the neutron-star equation of state is sufficiently stiff, we show that the total energy loss in the point-particle approximation is formally divergent. Various mechanisms -including viscosity, finite-size effects and the elasticity of the crust- can damp high-$l$ modes and regularize the total energy loss. Within a short time, the black hole is trapped inside the star and disrupts it by rapid accretion. Estimating these effects, we predict that the existence of old neutron stars in regions where the dark-matter density rho_{DM}>10^2 sigma/(km/s) GeV/cm^3 (where sigma is the dark-matter velocity dispersion) limits the abundance of primordial black holes in the mass range 10^{17} g < m_{PBH} < 10^{24} g, which was previously unconstrained. In combination with existing limits, our results suggest that primordial black holes cannot be the dominant dark matter constituent.

Tidal capture of a primordial black hole by a neutron star: implications for constraints on dark matter

Recent population studies have searched for a subpopulation of primordial black holes (PBHs) in the gravitational-wave (GW) events so far detected by LIGO/Virgo/KAGRA (LVK), in most cases adopting a phenomenological PBH mass distribution. When deriving such population from first principles in the standard scenario, however, the equation of state of the Universe at the time of PBH formation may strongly affect the PBH abundance and mass distribution, which ultimately depend on the power spectrum of cosmological perturbations. Here we improve on previous population studies on several aspects: (i) we adopt state-of-the-art PBH formation models describing the collapse of cosmological perturbations across the QCD epoch; (ii) we perform the first Bayesian multi-population inference on GW data including PBHs and directly using power spectrum parameters instead of phenomenological distributions; (iii) we critically confront the PBH scenario with LVK phenomenological models describing the GWTC-3 catalog both in the neutron-star and in the BH mass ranges, also considering PBHs as subpopulation of the total events. Our results confirm that LVK observations prevent the majority of the dark matter to be in the form of stellar mass PBHs. We find that the best fit PBH model can comprise a small fraction of the total events, in particular it can naturally explain events in the mass gaps. If the lower mass-gap event GW190814 is interpreted as a PBH binary, we predict that LVK should detect up to a few subsolar mergers and one to $\approx 30$ lower mass gap events during the upcoming O4 and O5 runs. Finally, mapping back the best-fit power spectrum into an ultra slow-roll inflationary scenario, we show that the latter predicts detectable PBH mergers in the LVK band, a stochastic GW background detectable by current and future instruments, and may include the entirety of dark matter in asteroid-mass PBHs.

From inflation to black hole mergers and back again: Gravitational-wave data-driven constraints on inflationary scenarios with a first-principle model of primordial black holes across the QCD epoch

Tidal deformability of dressed black holes and tests of ultralight bosons in extended mass ranges

Extreme mass-ratio inspirals (EMRIs) detectable by the Laser Interferometer Space Antenna (LISA) are unique probes of the nature of supermassive compact objects. We compute the gravitational-wave signal emitted by a stellar-mass compact object in a circular equatorial orbit around a Kerr-like horizonless supermassive object defined by an effective radius and a reflectivity coefficient. The Teukolsky equations are solved consistently with suitable (frequency-dependent) boundary conditions, and the modified energy and angular-momentum fluxes are used to evolve the orbital parameters adiabatically. The gravitational fluxes have resonances corresponding to the low-frequency quasinormal modes of the central object, which can contribute significantly to the gravitational-wave phase. Overall, the absence of a classical event horizon in the central object can affect the gravitational-wave signal dramatically, with deviations even larger than those previously estimated by a model-independent analysis of the tidal heating. We estimate that EMRIs could potentially place the most stringent constraint on the reflectivity of supermassive compact objects at the remarkable level of ${\cal O}(10^{-6})\%$ and would allow to constrain various models which are not ruled out by the ergoregion instability. In particular, an EMRI detection could allow to rule out (or provide evidence for) signatures of quantum black-hole horizons with Boltzmann reflectivity. Our results motivate performing rigorous parameter estimations to assess the detectability of these effects.

Paolo Pani

Papers

Hexose monophosphate shunt and cholesterol synthesis in the diabetic and fasting states.

Tidal capture of a primordial black hole by a neutron star: implications for constraints on dark matter

From inflation to black hole mergers and back again: Gravitational-wave data-driven constraints on inflationary scenarios with a first-principle model of primordial black holes across the QCD epoch

Tidal deformability of dressed black holes and tests of ultralight bosons in extended mass ranges

Extreme mass-ratio inspirals around a spinning horizonless compact object