P
Pär Gerwins
Researcher at Uppsala University
Publications - 31
Citations - 1731
Pär Gerwins is an academic researcher from Uppsala University. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor A. The author has an hindex of 18, co-authored 31 publications receiving 1537 citations. Previous affiliations of Pär Gerwins include Uppsala University Hospital.
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Function of fibroblast growth factors and vascular endothelial growth factors and their receptors in angiogenesis
TL;DR: This review will focus on two important types of angiogenic growth factors, vascular endothelial growth factor (VEGF) and fibroblast growth factors (FGF), which bind to cell surface expressed receptors, which are ligand-stimulatable tyrosine kinases.
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Biomechanical regulation of blood vessel growth during tissue vascularization.
TL;DR: It is shown here that neovascularization can be accomplished by nonangiogenic expansion of preexisting vessels by exploiting tissue tension generated by activated fibroblasts or myofibroblast during wound contraction mediated and directed translocation of the vasculature.
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p38 MAP kinase negatively regulates endothelial cell survival, proliferation, and differentiation in FGF-2-stimulated angiogenesis.
TL;DR: Results implicate p38 in organization of new vessels and suggest that p38 is an essential regulator of FGF-2–driven angiogenesis, which is suggested to be an essential regulation of growth factor–dependent cellular functions.
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Identification and characterization of VEGF-A–responsive neutrophils expressing CD49d, VEGFR1, and CXCR4 in mice and humans
Sara Massena,Gustaf Christoffersson,Evelina Vågesjö,Cedric Seignez,Karin Gustafsson,Francois Binet,Carmen Herrera Hidalgo,Antoine Giraud,Jalal Lomei,Simone Weström,Masabumi Shibuya,Lena Claesson-Welsh,Pär Gerwins,Michael Welsh,Johan Kreuger,Mia Phillipson +15 more
TL;DR: In this paper, the authors investigated the mechanisms underlying neutrophil recruitment to VEGF-A as well as the characteristics of these neutrophils, and found that parallel activation of VEGFR1 and VEGFC2 was required for VEGf-A-induced recruitment of circulating neutrophILS to tissue.
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Endocan is a VEGF-A and PI3K regulated gene with increased expression in human renal cancer.
Emma Rennel,Sofie Mellberg,Anna Dimberg,Ludvig Petersson,Johan Botling,Adam Ameur,Jakub Orzechowski Westholm,Jan Komorowski,Philippe Lassalle,Michael J. Cross,Pär Gerwins,Pär Gerwins +11 more
TL;DR: It is shown that, among angiogenic growth factors, VEGF-A is a specific inducer of endocan transcription which is translated into increased protein levels in VEGf-A treated endothelial cells.