M
Mia Phillipson
Researcher at Uppsala University
Publications - 98
Citations - 9622
Mia Phillipson is an academic researcher from Uppsala University. The author has contributed to research in topics: Mucus & Vascular endothelial growth factor A. The author has an hindex of 37, co-authored 90 publications receiving 7875 citations. Previous affiliations of Mia Phillipson include Science for Life Laboratory & University of Calgary.
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Journal ArticleDOI
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
Malin E. V. Johansson,Mia Phillipson,Joel Petersson,Anna Velcich,Lena Holm,Gunnar C. Hansson +5 more
TL;DR: Findings show that the Muc2 mucin can build a mucus barrier that separates bacteria from the colon epithelia and suggest that defects in this mucus can cause colon inflammation.
Journal ArticleDOI
Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade
TL;DR: In vivo results clearly delineate two fundamentally different molecular mechanisms for LFA-1 and Mac-1 in vivo, i.e., LFA–1–dependent adhesion followed by Mac- 1–dependent crawling, and both steps ultimately contribute to efficient emigration out of the vasculature.
Journal ArticleDOI
HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.
Charlotte Rolny,Massimiliano Mazzone,Sonia Tugues,Damya Laoui,Irja Johansson,Cathy Coulon,Mario Leonardo Squadrito,Inmaculada Segura,Xiujuan Li,Ellen Knevels,Sandra Costa,Stefan Vinckier,Tom Dresselaer,Peter Åkerud,Maria De Mol,Henriikka Salomäki,Mia Phillipson,Sabine Wyns,Erik G. Larsson,Ian Buysschaert,Johan Botling,Uwe Himmelreich,Jo A. Van Ginderachter,Michele De Palma,Mieke Dewerchin,Lena Claesson-Welsh,Peter Carmeliet +26 more
TL;DR: It is reported that the host-produced histidine-rich glycoprotein (HRG) inhibits tumor growth and metastasis, while improving chemotherapy, and offers therapeutic opportunities for anticancer and antiangiogenic treatment.
Journal ArticleDOI
The neutrophil in vascular inflammation.
Mia Phillipson,Paul Kubes +1 more
TL;DR: How neutrophils have a key regulatory role in vascular inflammation and how these processes may be disrupted in systemic infections is described, with a particular emphasis on mouse models of sepsis.
Journal ArticleDOI
Female Mice are Protected against High-Fat Diet Induced Metabolic Syndrome and Increase the Regulatory T Cell Population in Adipose Tissue
TL;DR: Female mice are protected against HFD-induced metabolic changes while maintaining an anti-inflammatory environment in the intra-abdominal adipose tissue with expanded Treg cell population, whereas HFD -fed male mice develop adipOSE tissue inflammation, glucose intolerance, hyperinsulinemia, and islet hypertrophy.