P
Paramasivam Krishnamoorthy
Researcher at Bharathiar University
Publications - 19
Citations - 1285
Paramasivam Krishnamoorthy is an academic researcher from Bharathiar University. The author has contributed to research in topics: Hydrazone & Ligand. The author has an hindex of 13, co-authored 19 publications receiving 1093 citations. Previous affiliations of Paramasivam Krishnamoorthy include Instituto Superior Técnico & Kongu Engineering College.
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Journal ArticleDOI
Evaluation of DNA binding, DNA cleavage, protein binding and in vitro cytotoxic activities of bivalent transition metal hydrazone complexes
Paramasivam Krishnamoorthy,Palanisamy Sathyadevi,Alan H. Cowley,Rachel R. Butorac,N. Dharmaraj +4 more
TL;DR: Assay on the cytotoxicity of Co, Ni and Cu hydrazone complexes against HeLa tumor cells and NIH 3T3 normal cells revealed that the complexes are toxic only against tumor cells but not to normal cells.
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Effect of substitution and planarity of the ligand on DNA/BSA interaction, free radical scavenging and cytotoxicity of diamagnetic Ni(II) complexes: A systematic investigation
Palanisamy Sathyadevi,Paramasivam Krishnamoorthy,Rachel R. Butorac,Alan H. Cowley,Nattamai Bhuvanesh,N. Dharmaraj +5 more
TL;DR: The effect of complexes 5-8 to arrest the growth of HeLa and Hep-2 tumour cell lines has been studied along with the cell viability against the non-cancerous NIH 3T3 cells under in vitro conditions.
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Copper(I) and nickel(II) complexes with 1 : 1 vs. 1 : 2 coordination of ferrocenyl hydrazone ligands: Do the geometry and composition of complexes affect DNA binding/cleavage, protein binding, antioxidant and cytotoxic activities?
Paramasivam Krishnamoorthy,Palanisamy Sathyadevi,Rachel R. Butorac,Alan H. Cowley,Nattamai Bhuvanesh,N. Dharmaraj +5 more
TL;DR: Systematic biological investigations like DNA binding, DNA cleavage, protein binding,protein binding, free radical scavenging and cytotoxicity activities were carried out using all the synthesised compounds and the results obtained were explained on the basis of structure-activity relationships.
Journal ArticleDOI
Studies on the effect of metal ions of hydrazone complexes on interaction with nucleic acids, bovine serum albumin and antioxidant properties
Palanisamy Sathyadevi,Paramasivam Krishnamoorthy,Eswaran Jayanthi,Rachel R. Butorac,Alan H. Cowley,N. Dharmaraj +5 more
TL;DR: In this paper, three transition metal complexes of the type ML2 (where M = Ni, Co, or Cu(II); HL = N′-[phenyl(pyridin-2-yl)methylidene] furoic acid hydrazide and 2-benzoyl pyridine] have been prepared by treating [NiCl2(PPh3)2], [CoCl2 (PPh 3)2] or [CuCl2[PPh4] with N′]-phenyl-pyrin-two-ylmethyl
Journal ArticleDOI
Synthesis of novel heterobimetallic copper(I) hydrazone Schiff base complexes: A comparative study on the effect of heterocyclic hydrazides towards interaction with DNA/protein, free radical scavenging and cytotoxicity
Palanisamy Sathyadevi,Paramasivam Krishnamoorthy,Rachel R. Butorac,Alan H. Cowley,N. Dharmaraj +4 more
TL;DR: Two new copper(I) hydrazone complexes have been synthesised from bivalent copper precursor [CuCl(2)(PPh(3))(2)] and ferrocene containing bidentate hydraz one ligands HL(1) or HL(2) (2) based on the elemental analyses and spectroscopic data.