There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.

Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

I and i

[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

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An Introduction To Medicinal Chemistry

In recent years, the number of people suffering from cancer and multidrug-resistant infections has sharply increased, leaving humanity without any choice but to search for new treatment options and strategies. Although cancer is considered the leading cause of death worldwide, it also paves the way many microbial infections and thus increases this burden manifold. Development of small molecules as anticancer and anti-microbial agents has great potential and a plethora of drugs are already available to combat these diseases. However, the wide occurrence of multidrug resistance in both cancer and microbial infections necessitates the development of new and potential molecules with desired properties that could circumvent the multidrug resistance problem. A successful strategy in anticancer chemotherapy has been the use of metallo-drugs and this strategy has the potential to be used for treating multidrug-resistant infections more efficiently. As a class of molecules, Schiff bases have been the topic of considerable interest, owing to their versatile metal chelating properties, inherent biological activities and flexibility to modify the structure to fine-tune it for a particular biological application. Schiff base-based metallo-drugs are being researched to develop new anticancer and anti-microbial chemotherapies and because both anticancer and anti-microbial targets are different, heterocyclic Schiff bases can be structurally modified to achieve the desired molecule, targeting a particular disease. In this review, we collect the most recent and relevant literature concerning the synthesis of heterocyclic Schiff base metal complexes as anticancer and anti-microbial agents and discuss the potential and future of this class of metallo-drugs as either anticancer or anti-microbial agents.

/pdf/heterocyclic-schiff-base-transition-metal-complexes-in-2byu9iy4ry.pdf

Heterocyclic Schiff base transition metal complexes in antimicrobial and anticancer chemotherapy.

Ion beam induced surface and interface engineering

Microstructural evolution during reactive brazing of alumina to Inconel 600 using Ag-based alloy

A novel Schiff base ligand of type HL was prepared by the condensation of amoxicillin trihydrate and nicotinaldehyde. The metal complexes of Co+2, Ni+2, Cu+2, and Zn+2 were characterized and investigated by physical and spectral techniques, namely, elemental analysis, melting point, conductivity, 1H NMR, IR, UV-Vis spectra, ESR, SEM, and mass spectrometry measurements. They were further analyzed by thermal technique (TGA/DTA) to gain better insight about the thermal stability and kinetic properties of the complexes. Thermal data revealed high thermal stability and nonspontaneous nature of the decomposition steps. The Coats-Redfern method was applied to extract thermodynamic parameters to explain the kinetic behavior. The molar conductance values were relatively low, showing their nonelectrolytic nature. The powder XRD pattern revealed amorphous nature except copper complex (1c) that crystallized in the triclinic crystal system. The EPR study strongly recommends the tetrahedral geometry of 1c. The structure optimization by MM force field calculation through ArgusLab 4.0.1 software program supports the concerned geometry of the complexes. The in vitro antibacterial activity of all the compounds, at their two different concentrations, was screened against four bacterial pathogens, namely, E. coli, P. vulgaris, K. pneumoniae, and S. aureus, and showed better activity compared to parent drug and control drug.

/pdf/metal-complexes-of-a-novel-schiff-base-based-on-penicillin-3rjhuo3qef.pdf

Metal Complexes of a Novel Schiff Base Based on Penicillin: Characterization, Molecular Modeling, and Antibacterial Activity Study

The development of a novel and portable tabletop pulsed neutron source is presented. It is a battery powered neutron tube based on a miniature plasma focus (PF) device having all metal-sealed components. The tube, fuelled with deuterium gas, generates neutrons because of D–D fusion reactions. The inner diameter and the length of the tube are 3.4 cm and 8 cm, respectively. A single capacitor (200 J, 4.0 µF, 10 nH) of compact size (17 cm × 15 cm × 13 cm, 6.5 kg) is used as the energy driver. A power supply system charges the capacitor to 10 kV in 10 s and also provides a 30 kV trigger pulse to the spark gap. An input of 24 V dc (7.5 A) to the power supply system is provided by two rechargeable batteries (each 12 V, 7.5 A, 20 h). The device has produced neutrons for 150 shots within a period of 120 days in a very reliable manner without purging the deuterium gas between the shots. For the first 50 shots, the average yield is (1.6 ± 0.3) × 106 neutrons/shot in 4π sr with a pulse width of 23.4 ± 3.3 ns. The estimated neutron energy is 2.47 ± 0.22 MeV. The neutron production reduces slowly and reaches the detection threshold value of 3 × 105 neutrons/shot towards the last shots. The device produces neutrons in a similar manner on evacuation and refilling. The height of the mounted PF tube with the capacitor and the spark gap is 35 cm. The complete setup comprising the capacitor with spark gap, the PF tube, the power supply system with two batteries and the control panel weighs only 23 kg.

https://iopscience.iop.org/article/10.1088/0022-3727/41/20/205211/pdf

Battery powered tabletop pulsed neutron source based on a sealed miniature plasma focus device

Aluminum nitride thin films were deposited on Si (100) substrate by pulsed DC (asymmetric bipolar) reactive magnetron sputtering under variable nitrogen flow in a gas mixture of argon and nitrogen. The deposited film was characterized by grazing incidence X-ray diffraction (GIXRD), atomic force microscope (AFM), spectroscopic ellipsometry, and secondary ion mass spectroscopy (SIMS). GIXRD results have shown (100) reflection of wurtzite AlN, whereas AFM micrographs have revealed very fine grained microstructure with average roughness in the range 6–8 nm. Spectroscopic ellipsometry measurements have indicated the band gap and refractive index of the film in the range 5.0–5.48 eV and 1.58–1.84, respectively. SIMS measurement has indicated the presence of oxygen in the film.

/pdf/structural-and-optical-properties-of-aluminum-nitride-thin-h1o00avgte.pdf

Structural and Optical Properties of Aluminum Nitride Thin Films Deposited by Pulsed DC Magnetron Sputtering

Spectroscopic, electrochemical and biological studies of the metal complexes of the Schiff base derived from pyrrole-2-carbaldehyde and ethylenediamine

Parashuram Mishra

Papers

Microstructural evolution during reactive brazing of alumina to Inconel 600 using Ag-based alloy

Metal Complexes of a Novel Schiff Base Based on Penicillin: Characterization, Molecular Modeling, and Antibacterial Activity Study

Battery powered tabletop pulsed neutron source based on a sealed miniature plasma focus device

Structural and Optical Properties of Aluminum Nitride Thin Films Deposited by Pulsed DC Magnetron Sputtering

Spectroscopic, electrochemical and biological studies of the metal complexes of the Schiff base derived from pyrrole-2-carbaldehyde and ethylenediamine