Showing papers by "Patoomratana Tuchinda published in 2019"
TL;DR: Ethanolic extracts of ginger are tested for their ability to inhibit biofilm formation by an AHPND-causing isolate of V. parahaemolyticus using chitosan coated 96-well polystyrene plastic plates to mimic the shrimp stomach lining.
18 citations
TL;DR: Data indicated that ECDD-S27 retards the autophagy pathway by targeting the V-ATPase and inhibits cancer cell survival, and the observed antitumor activity without cytotoxicity to normal cells suggests the therapeutic potential warranting further studies on lead optimization of the compound for cancer treatment.
Abstract: Autophagy is a conserved lysosomal-dependent cellular degradation process and its dysregulation has been linked to numerous diseases including neurodegeneration, infectious diseases, and cancer. Modulation of autophagy is therefore considered as an attractive target for disease intervention. We carried out a high-content image analysis screen of natural product-derived compounds to discover novel autophagy modulating molecules. Our screen identified ECDD-S27 as the most effective compound for increasing the number of autophagic vacuoles inside cells. The structure of ECDD-S27 revealed that it is a derivative of cleistanthin A, a natural arylnaphthalene lignan glycoside found in plants. ECDD-S27 increases the number of autophagic vacuoles by inhibiting the autophagic flux and is able to restrict the survival of different cancer cells at low nanomolar concentrations. Molecular docking and SERS analysis showed that ECDD-S27 may potentially target the V-ATPase. Upon treatment of various cancer cells with ECDD-S27, the V-ATPase activity is potently inhibited thereby resulting in the loss of lysosomal acidification. Taken together, these data indicated that ECDD-S27 retards the autophagy pathway by targeting the V-ATPase and inhibits cancer cell survival. The observed antitumor activity without cytotoxicity to normal cells suggests the therapeutic potential warranting further studies on lead optimization of the compound for cancer treatment.
9 citations
TL;DR: A new lignan, thoreliin A (1), and a new bisnorlignan B (2), were isolated from a MeOH extract of the rhizomes of Boesenbergia thorelii and the relative stereochemistry of 1 was confirmed and their structures were elucidated based on their spectroscopic data.
7 citations
TL;DR: This study is the first evidence showing that P. taxodiifolius extract suppresses invasive properties of glioblastoma cells by disrupting microtubule structure and interfering with microtubules dynamics, suggesting the possibility to further develop P.Taxodiifolinius and its bioactive compounds as an anti-cancer drug targeting micro Tubule dynamics in gliOBlastoma.
2 citations