W
Witchuda Saengsawang
Researcher at Mahidol University
Publications - 26
Citations - 493
Witchuda Saengsawang is an academic researcher from Mahidol University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 9, co-authored 19 publications receiving 391 citations. Previous affiliations of Witchuda Saengsawang include University of Illinois at Chicago & University of Wisconsin-Madison.
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Journal ArticleDOI
Synaptic Regulation of Microtubule Dynamics in Dendritic Spines by Calcium, F-Actin, and Drebrin
Elliott B. Merriam,Matthew M. Millette,Derek C. Lumbard,Witchuda Saengsawang,Witchuda Saengsawang,Thomas Fothergill,Xindao Hu,Lotfi Ferhat,Erik W. Dent +8 more
TL;DR: It is shown that in hippocampal neurons from male and female mice, the majority of microtubules enter spines from highly localized sites at the base of spines in response to synapse-specific calcium transients that promote microtubule entry into active spines.
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Regulation of ubiquitin-dependent cargo sorting by multiple endocytic adaptors at the plasma membrane
Jonathan R. Mayers,Lei Wang,Jhuma Pramanik,Adam Johnson,Ali Sarkeshik,Yueju Wang,Witchuda Saengsawang,John R. Yates,Anjon Audhya +8 more
TL;DR: It is demonstrated that multiple plasma membrane endocytic adaptors function redundantly to regulate clathrin-mediated endocytosis and to recruit components of the endosomal sorting complex required for transport (ESCRT) machinery to the cell surface to direct the sorting of ubiquitin-modified substrates.
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Heterotrimeric G-Proteins Interact Directly with Cytoskeletal Components to Modify Microtubule-Dependent Cellular Processes
TL;DR: The role of tubulin and microtubules in directly mediating effects of heterotrimeric G-proteins on neuronal outgrowth, shape and differentiation and their role in synaptic plasticity is reviewed.
Journal ArticleDOI
The F-BAR Protein CIP4 Inhibits Neurite Formation by Producing Lamellipodial Protrusions
Witchuda Saengsawang,Kelly A. Mitok,Chris Viesselmann,Lauren Pietila,Derek C. Lumbard,Seth J. Corey,Erik W. Dent +6 more
TL;DR: This is the first study to demonstrate that an F-BAR protein functions differently in neuronal versus nonneuronal cells and induces lamellipodial protrusions instead of invaginations or filopodia-like structures.
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Structural model of a complex between the heterotrimeric G protein, Gsα, and tubulin
Brian T. Layden,Witchuda Saengsawang,Robert J. Donati,Shuo Yang,Debbie C. Mulhearn,Michael E. Johnson,Mark M. Rasenick +6 more
TL;DR: Structural models explain the able of tubulin to facilitate GTP exchange on Galpha and the ability of Galpha to activate tubulin GTPase.