Showing papers by "Patric J. Jansson published in 2018"
TL;DR: In this paper, a biochemically integrated link between iron and polyamine metabolism was found in cancer cells, since iron levels are also high in cancer, and like polyamines, are required for proliferation.
118 citations
TL;DR: Vital mitochondrial homeostatic processes and their roles in FA pathogenesis will be discussed, including mitochondrial iron processing, mitochondrial dynamics, mitophagy, mitochondrial biogenesis, mitochondrial energy production and calcium metabolism.
38 citations
TL;DR: This investigation describes a novel approach to overcoming resistance in the stressful tumor micro-environment by identifying two mechanisms that induced Pgp-mediated drug resistance and resulted in the agent overcoming resistance.
34 citations
TL;DR: In this article, a multi-functional adamantane-based semicarbazones and hydrazones targeting Alzheimer's disease (AD) hallmarks, including β-amyloid aggregation, oxidative stress, and metal dys-homeostasis, were designed.
Abstract: Alzheimer's disease (AD) is characterized by multiple pathological hallmarks, including β-amyloid aggregation, oxidative stress, and metal dys-homeostasis. In the absence of treatments addressing its multi-factorial pathology, we designed novel multi-functional adamantane-based semicarbazones and hydrazones (1-12) targeting AD hallmarks. Of these, 2-pyridinecarboxaldehyde (N-adamantan-1-yl)benzoyl-4-amidohydrazone (10) was identified as the lead compound, which demonstrated: (1) pronounced iron chelation efficacy; (2) attenuation of CuII-mediated β-amyloid aggregation; (3) low cytotoxicity; (4) inhibition of oxidative stress; and (5) favorable characteristics for effective blood-brain barrier permeation. Structure-activity relationships revealed that pyridine-derived hydrazones represent a promising pharmacophore for future design strategies due to their ability to bind critical FeII pools. Collectively, the unique multi-functional activity of these agents provides a novel therapeutic strategy for AD treatment.
31 citations
TL;DR: Results indicate the N-terminus region and phosphorylation at Ser330 could be crucial for NDRG1 nuclear localization and function and PTEN silencing indicated that p-NDRG 1 (Thr346) could be regulated differentially in different tumor cell-types, indicating PTEN may be involved in the mechanism(s) underlying the pleiotropic activity of NDRg1.
30 citations
TL;DR: For the first time, it is demonstrated that cellular iron levels robustly regulate 13 polyamine pathway proteins and the "reprogramming" of polyamine metabolism by iron-depletion is consistent with the down-regulation of ADI1 and MAT2α, and the up- regulation of SAT1.
22 citations