P
Patricia A. Spears
Researcher at University of North Carolina at Chapel Hill
Publications - 27
Citations - 873
Patricia A. Spears is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 8, co-authored 21 publications receiving 282 citations. Previous affiliations of Patricia A. Spears include North Carolina State University College of Veterinary Medicine.
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Journal ArticleDOI
Neoadjuvant Chemotherapy, Endocrine Therapy, and Targeted Therapy for Breast Cancer: ASCO Guideline
Larissa A. Korde,Mark R. Somerfield,Lisa A. Carey,Jennie R. Crews,Neelima Denduluri,E. Shelley Hwang,Seema A. Khan,Sibylle Loibl,Elizabeth A. Morris,Alejandra T. Perez,Meredith M. Regan,Patricia A. Spears,Preeti Sudheendra,W. Fraser Symmans,Rachel L. Yung,Brittany E. Harvey,Dawn L. Hershman +16 more
TL;DR: An Expert Panel to conduct a systematic review of the literature on neoadjuvant therapy for breast cancer and provide recommended care options found insufficient evidence to support adding immune checkpoint inhibitors to standard chemotherapy.
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Composite grading algorithm for the National Cancer Institute’s Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE):
Ethan Basch,Claus Becker,Lauren J. Rogak,Deborah Schrag,Bryce B. Reeve,Patricia A. Spears,Mary Lou Smith,Mrinal M. Gounder,Michelle R. Mahoney,Gary K. Schwartz,Antonia V. Bennett,Tito R. Mendoza,Charles S. Cleeland,Jeff A. Sloan,Deborah Watkins Bruner,Gisela Schwab,Thomas M. Atkinson,Gita Thanarajasingam,Monica M. Bertagnolli,Amylou C. Dueck +19 more
TL;DR: A composite grading algorithm has been developed and yields single numerical grades for adverse events assessed via the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events, and can be useful in analyses and reporting.
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Clinical Utility and User Perceptions of a Digital System for Electronic Patient-Reported Symptom Monitoring During Routine Cancer Care: Findings From the PRO-TECT Trial.
Ethan Basch,Angela M. Stover,Deborah Schrag,Arlene E. Chung,Jennifer Jansen,Sydney Henson,Philip M Carr,Brenda Ginos,Allison M. Deal,Patricia A. Spears,Mattias Jonsson,Antonia V. Bennett,Gita N. Mody,Gita Thanarajasingam,Lauren J. Rogak,Bryce B. Reeve,Claire F. Snyder,Lisa A. Kottschade,Marjory Charlot,Anna Weiss,Deborah Watkins Bruner,Amylou C. Dueck +21 more
TL;DR: These findings support the clinical utility and value of implementing digital systems for monitoring PROs, including the PRO-CTCAE, in routine cancer care.
Journal ArticleDOI
Management of the Axilla in Early-Stage Breast Cancer: Ontario Health (Cancer Care Ontario) and ASCO Guideline.
Muriel Brackstone,Fulvia Baldassarre,Francisco E. Perera,Tulin Cil,Mariana Chavez-Mac Gregor,Ian S. Dayes,Jay Engel,Janet K. Horton,Tari A. King,Anat Kornecki,Ralph George,Sandip SenGupta,Patricia A. Spears,Andrea Eisen +13 more
TL;DR: In this article, the authors provide recommendations on the best strategies for axilla management and the best timing and treatment (surgical and radiotherapeutic) of axilla for patients with early stage breast cancer.
Journal ArticleDOI
Integrated Analysis of RNA and DNA from the Phase III Trial CALGB 40601 Identifies Predictors of Response to Trastuzumab-Based Neoadjuvant Chemotherapy in HER2-Positive Breast Cancer
Maki Tanioka,Cheng Fan,Joel S. Parker,Katherine A. Hoadley,Zhiyuan Hu,Yan Li,Terry Hyslop,Brandelyn N. Pitcher,Matthew G. Soloway,Patricia A. Spears,Lynn N. Henry,Sara M. Tolaney,Chau T. Dang,Ian E. Krop,Lyndsay Harris,Donald A. Berry,Elaine R. Mardis,Eric P. Winer,Clifford A. Hudis,Lisa A. Carey,Charles M. Perou +20 more
TL;DR: Integrative analyses showed that models containing gene signatures, clinical features, and DNA information were better pCR predictors than models containing a single data type, as well as integrated RNA and DNA models.