Patricia Bray-Ward

TL;DR: Rolling-circle amplification (RCA) driven by DNA polymerase can replicate circularized oligonucleotide probes with either linear or geometric kinetics under isothermal conditions, making it particularly amenable for the analysis of rare somatic mutations.

TL;DR: MDA-based whole genome amplification by multiple displacement amplification is a simple and reliable method that could have significant implications for genetic studies, forensics, diagnostics, and long-term sample storage.

TL;DR: The cloning of a t(12;21) translocation breakpoint involving 12p13 and 21q22 in two cases of childhood pre-B acute lymphoblastic leukemia shows that TEL, previously shown to be fused to the platelet-derived growth factor receptor beta in chronic myelomonocytic leukemia, can be implicated in the pathogenesis of leukemia through its fusion to either a receptor tyrosine kinase or a transcription factor.

TL;DR: A blood test, based on the simultaneous quantization of four analytes (leptin, prolactin, osteopontin, and insulin-like growth factor-II), that can discriminate between disease-free and EOC patients, including patients diagnosed with stage I and II disease, with high efficiency is reported.

TL;DR: A reproducible protocol for slide preparation, aging, and hybridization that yields good chromosome spreads from even the most difficult cell suspensions and is unaffected by the environmental conditions is developed.