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Patricia L. Blount
Researcher at Fred Hutchinson Cancer Research Center
Publications - 72
Citations - 8878
Patricia L. Blount is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Barrett's esophagus & Esophagus. The author has an hindex of 45, co-authored 72 publications receiving 8614 citations. Previous affiliations of Patricia L. Blount include University of Tennessee & Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
Genetic clonal diversity predicts progression to esophageal adenocarcinoma
Carlo C. Maley,Patricia C. Galipeau,Jennifer C. Finley,V. Jon Wongsurawat,Xiaohong Li,Carissa A. Sanchez,Thomas G. Paulson,Patricia L. Blount,Patricia L. Blount,Rosa Ana Risques,Peter S. Rabinovitch,Peter S. Rabinovitch,Brian J. Reid +12 more
TL;DR: It is shown that clonal diversity measures adapted from ecology and evolution can predict progression to adenocarcinoma in the premalignant condition known as Barrett's esophagus, even when controlling for established genetic risk factors.
Journal ArticleDOI
Predictors of progression to cancer in Barrett's esophagus: baseline histology and flow cytometry identify low- and high-risk patient subsets.
Brian J. Reid,Douglas S. Levine,Gary Longton,Patricia L. Blount,Patricia L. Blount,Peter S. Rabinovitch +5 more
TL;DR: A systematic baseline endoscopic biopsy protocol using histology and flow cytometry identifies subsets of patients with Barrett's esophagus at low and high risk for progression to cancer as mentioned in this paper.
Journal ArticleDOI
An endoscopic biopsy protocol can differentiate high-grade dysplasia from early adenocarcinoma in Barrett's esophagus
Douglas S. Levine,Rodger C. Haggitt,Rodger C. Haggitt,Patricia L. Blount,Patricia L. Blount,Peter S. Rabinovitch,Peter S. Rabinovitch,Valerie W. Rusch,Valerie W. Rusch,Brian J. Reid,Brian J. Reid +10 more
TL;DR: This endoscopic protocol accurately detects and differentiates high-grade dysplasia from early adenocarcinoma in Barrett's esophagus and does not necessarily require surgical resection to rule out an undiagnosed adenOCarcinomas.
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Flow-cytometric and histological progression to malignancy in Barrett's esophagus: Prospective endoscopic surveillance of a cohort
Brian J. Reid,Patricia L. Blount,Cyrus E. Rubin,Douglas S. Levine,Rodger C. Haggitt,Peter S. Rabinovitch +5 more
TL;DR: Nine of 13 patients who showed aneuploid or increased G2/tetraploid populations in their initial flow-cytometric analysis developed high-grade dysplasia or adenocarcinoma during follow-up, but none of the 49 patients without these abnormalities progressed to high- grade dysplia or cancer.
Journal ArticleDOI
Predictors of progression in Barrett's esophagus II: baseline 17p (p53) loss of heterozygosity identifies a patient subset at increased risk for neoplastic progression.
Brian J. Reid,Laura J. Prevo,Patricia C. Galipeau,Carissa A. Sanchez,Gary Longton,Douglas S. Levine,Patricia L. Blount,Patricia L. Blount,Peter S. Rabinovitch +8 more
TL;DR: Predictors of progression in Barrett's esophagus II: baseline 17p (p53) loss of heterozygosity identifies a patient subset at increased risk for neoplastic progression.