Patricia L. Brubaker

TL;DR: It is demonstrated that nude mice bearing subcutaneous proglucagon-producing tumors exhibit marked proliferation of the small intestinal epithelium, defining a novel biological role for GLP-2 as an intestinal-derived peptide stimulator of small bowel epithelial proliferation.

TL;DR: It is demonstrated that GLP1 plays a central role in the regulation of glycemia; however, disruption of GLP 1/GLP1R signaling in the central nervous system is not associated with perturbation of feeding behavior or obesity in vivo.

TL;DR: This article showed that glucagon-like peptides (GLP-1 and GLP-2) directly regulate signaling pathways coupled to cell proliferation and apoptosis, which may be mediated by direct or indirect effects on target cells.

TL;DR: The results of these experiments demonstrate that the secretion of GLP-1 and gGLI from the ileal L cell in response to fat is regulated by a complex neuroendocrine loop, involving the enteric nervous system, the afferent and efferent vagus nerves, as well as the duodenal hormone GIP.

TL;DR: It is shown that β-catenin and the glycogen synthase kinase-3β inhibitor lithium do not activate glu mRNA or glu promoter expression in pancreatic cell lines, and stable introduction of dominant-negative TCF-4 into the GLUTag cell line repressed basal glu RNA expression and abolished the effect of lithium onglu mRNA expression and GLP-1 synthesis.