P
Patricio B. Lynn
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 40
Citations - 1922
Patricio B. Lynn is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Neoadjuvant therapy & Total mesorectal excision. The author has an hindex of 12, co-authored 33 publications receiving 1431 citations. Previous affiliations of Patricio B. Lynn include New York University.
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Journal ArticleDOI
Local Recurrence After Complete Clinical Response and Watch and Wait in Rectal Cancer After Neoadjuvant Chemoradiation: Impact of Salvage Therapy on Local Disease Control
Angelita Habr-Gama,Joaquim Gama-Rodrigues,Guilherme Pagin São Julião,Igor Proscurshim,Charles Sabbagh,Patricio B. Lynn,Rodrigo Oliva Perez +6 more
TL;DR: Local recurrence may develop in 31% of patients with initial cCR when early regrowths (≤ 12 months) and late recurrences are grouped together, and more than half of these recurrence develop within 12 months of follow-up.
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Assessment of a Watch-and-Wait Strategy for Rectal Cancer in Patients With a Complete Response After Neoadjuvant Therapy
J. Joshua Smith,Paul Strombom,Oliver S. Chow,Campbell S.D. Roxburgh,Campbell S.D. Roxburgh,Patricio B. Lynn,Anne Eaton,Maria Widmar,Karuna Ganesh,Rona Yaeger,Andrea Cercek,Martin R. Weiser,Garrett M. Nash,Jose G. Guillem,Larissa K. Temple,Sree Bhavani Chalasani,James L. Fuqua,Iva Petkovska,Abraham J. Wu,Marsha Reyngold,Efsevia Vakiani,Jinru Shia,Neil H. Segal,James D. Smith,Christopher H. Crane,Marc J. Gollub,Mithat Gonen,Leonard B. Saltz,Julio Garcia-Aguilar,Philip B. Paty +29 more
TL;DR: A WW strategy for select rectal cancer patients who had a clinical complete response after neoadjuvant therapy resulted in excellent rectal preservation and pelvic tumor control; however, in the WW group, worse survival was noted along with a higher incidence of distant progression in patients with local reg growth vs those without local regrowth.
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Organ preservation for clinical T2N0 distal rectal cancer using neoadjuvant chemoradiotherapy and local excision (ACOSOG Z6041): results of an open-label, single-arm, multi-institutional, phase 2 trial
Julio Garcia-Aguilar,Lindsay A. Renfro,Oliver S. Chow,Qian Shi,Xiomara W. Carrero,Patricio B. Lynn,Charles R. Thomas,Emily Chan,Peter A. Cataldo,Jorge E. Marcet,David S. Medich,Craig S. Johnson,Samuel Oommen,Bruce G. Wolff,Alessio Pigazzi,Shane M McNevin,Roger K Pons,Ronald Bleday +17 more
TL;DR: The data suggest that nCRT followed by LE may be considered as an organ-preserving alternative in carefully selected patients with clinically-staged T2N0 tumours who refuse, or are not candidates for, transabdominal resection.
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Accuracy of positron emission tomography/computed tomography and clinical assessment in the detection of complete rectal tumor regression after neoadjuvant chemoradiation: long-term results of a prospective trial (National Clinical Trial 00254683).
Rodrigo Oliva Perez,Angelita Habr-Gama,Joaquim Gama-Rodrigues,Igor Proscurshim,Guilherme Pagin São Julião,Patricio B. Lynn,Carla Rachel Ono,Fábio Campos,Afonso Henrique da Silva e Sousa,Antonio Rocco Imperiale,Sergio Carlos Nahas,Carlos Alberto Buchpiguel +11 more
TL;DR: Assessment of tumor response with positron emission tomography/computed tomography (PET/CT) after neoadjuvant treatment may offer relevant information for the selection of patients to receive alternative treatment strategies.
Journal ArticleDOI
Transanal endoscopic microsurgery for residual rectal cancer (ypT0-2) following neoadjuvant chemoradiation therapy: another word of caution.
Rodrigo Oliva Perez,Angelita Habr-Gama,Patricio B. Lynn,Guilherme Pagin São Julião,Romina Bianchi,Igor Proscurshim,Joaquim Gama-Rodrigues +6 more
TL;DR: A local failure rate of 15% after transanal endoscopic microsurgery for patients with residual rectal cancers restricted to the bowel wall (ypT0-2) may limit the indication of this procedure to highly selected patients as an alternative to standard radical total mesorectal excision.