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Patrick A. Hughes
Researcher at University of Adelaide
Publications - 54
Citations - 3375
Patrick A. Hughes is an academic researcher from University of Adelaide. The author has contributed to research in topics: Visceral pain & Inflammatory bowel disease. The author has an hindex of 25, co-authored 54 publications receiving 2771 citations. Previous affiliations of Patrick A. Hughes include Boston Children's Hospital & Royal Adelaide Hospital.
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Journal ArticleDOI
Effect of Fecal Microbiota Transplantation on 8-Week Remission in Patients With Ulcerative Colitis: A Randomized Clinical Trial.
Samuel P Costello,Samuel P Costello,Patrick A. Hughes,Oliver Waters,Robert V Bryant,Robert V Bryant,Andrew D. Vincent,Paul Blatchford,Rosa Katsikeros,Jesica Makanyanga,Melissa A. Campaniello,Chris Mavrangelos,Carly P. Rosewarne,Chelsea Bickley,Cian Peters,Mark Schoeman,Mark Schoeman,Michael A. Conlon,Ian C. Roberts-Thomson,Jane M. Andrews,Jane M. Andrews +20 more
TL;DR: In this preliminary study of adults with mild to moderate UC, 1-week treatment with anaerobically prepared donor FMT compared with autologous FMT resulted in a higher likelihood of remission at 8 weeks.
Journal ArticleDOI
The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli.
Stuart M. Brierley,Stuart M. Brierley,Patrick A. Hughes,Patrick A. Hughes,Amanda J. Page,Amanda J. Page,Kelvin Y. Kwan,Christopher M. Martin,Tracey A. O'Donnell,Nicole J. Cooper,Andrea M. Harrington,B. Adam,Tobias Liebregts,Gerald Holtmann,Gerald Holtmann,David P. Corey,Grigori Y. Rychkov,L. Ashley Blackshaw,L. Ashley Blackshaw +18 more
TL;DR: These findings demonstrate a previously unrecognized role for TRPA1 in normal and inflamed mechanosensory function and nociception within the viscera.
Journal ArticleDOI
Selective Role for TRPV4 Ion Channels in Visceral Sensory Pathways
Stuart M. Brierley,Amanda J. Page,Amanda J. Page,Patrick A. Hughes,Patrick A. Hughes,B. Adam,Tobias Liebregts,Nicole J. Cooper,Gerald Holtmann,Gerald Holtmann,Wolfgang Liedtke,L. Ashley Blackshaw,L. Ashley Blackshaw +12 more
TL;DR: It is proposed that TRPV4 may present a selective novel target for the reduction of visceral pain, which is an important opportunity in the absence of current treatments.
Journal ArticleDOI
Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3',5'-monophosphate.
Joel Castro,Joel Castro,Andrea M. Harrington,Andrea M. Harrington,Patrick A. Hughes,Patrick A. Hughes,Christopher M. Martin,Pei Ge,Courtney Shea,Hong Jin,Sarah Jacobson,Gerhard Hannig,Elizabeth A. Mann,Mitchell B. Cohen,James E. MacDougall,Bernard J. Lavins,Caroline B. Kurtz,Inmaculada Silos-Santiago,Jeffrey M. Johnston,Mark G. Currie,L. Ashley Blackshaw,L. Ashley Blackshaw,Stuart M. Brierley,Stuart M. Brierley +23 more
TL;DR: An analgesic mechanism of linaclotide is identified: it activates GC-C expressed on mucosal epithelial cells, resulting in the production and release of cGMP, which reduces nociception in patients with IBS-C.
Linaclotide Inhibits Colonic Nociceptors and Relieves Abdominal Pain via Guanylate Cyclase-C and Extracellular Cyclic Guanosine
Joel Castro,Andrea M. Harrington,Patrick A. Hughes,Christopher M. Martin,Pei Ge,Courtney Shea,Hong Jin,Sarah Jacobson,Gerhard Hannig,Elizabeth A. Mann,Mitchell B. Cohen,James E. MacDougall,Bernard J. Lavins,Caroline B. Kurtz,Inmaculada Silos-Santiago,Jeffrey M. Johnston,Mark G. Currie,L. Ashley Blackshaw,Stuart M. Brierley +18 more