Stuart M. Brierley

TL;DR: C cultured intestinal organoids are exploited together with single-cell measurements to elucidate intrinsic biophysical, pharmacological, and genetic properties of EC cells, showing that EC cells express specific chemosensory receptors, are electrically excitable, and modulate serotonin-sensitive primary afferent nerve fibers via synaptic connections, enabling them to detect and transduce environmental, metabolic, and homeostatic information from the gut directly to the nervous system.

TL;DR: The splanchnic and pelvic pathways contain distinct populations of mechanosensitive afferents, which are capable of detecting an array of mechanical stimuli and are individually tuned to detect the type, magnitude, and duration of the stimulus.

TL;DR: These data show that ASIC3 makes a critical positive contribution to mechanosensitivity in three out of four classes of visceral afferents, suggesting that targeting these subunits with pharmacological agents may have different and more pronounced effects on mechanos sensitivity in the viscera.

TL;DR: These findings demonstrate a previously unrecognized role for TRPA1 in normal and inflamed mechanosensory function and nociception within the viscera.

TL;DR: It is proposed that TRPV4 may present a selective novel target for the reduction of visceral pain, which is an important opportunity in the absence of current treatments.