P
Patrick B. Hamilton
Researcher at Manchester Royal Infirmary
Publications - 82
Citations - 3927
Patrick B. Hamilton is an academic researcher from Manchester Royal Infirmary. The author has contributed to research in topics: Trypanosoma & Population. The author has an hindex of 32, co-authored 76 publications receiving 3439 citations. Previous affiliations of Patrick B. Hamilton include University of Bristol & University of Exeter.
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Journal ArticleDOI
Randomized Trial of C5a Receptor Inhibitor Avacopan in ANCA-Associated Vasculitis.
David Jayne,Annette Bruchfeld,Lorraine Harper,Matthias Schaier,Michael Venning,Patrick B. Hamilton,Volker Burst,Franziska Grundmann,Michel Jadoul,Istvan Szombati,Vladimír Tesař,Mårten Segelmark,Antonia Potarca,Thomas J. Schall,Pirow Bekker +14 more
TL;DR: In conclusion, C5a receptor inhibition with avacopan was effective in replacing high-dose glucocorticoids in treating vasculitis.
Journal ArticleDOI
Populations of a cyprinid fish are self-sustaining despite widespread feminization of males
Patrick B. Hamilton,Elizabeth Nicol,Eliane S. R. De-Bastos,Richard J. Williams,John P. Sumpter,Susan Jobling,Jamie R. Stevens,Charles R. Tyler +7 more
TL;DR: Examining population genetic structures and effective population sizes of wild roach living in English rivers contaminated with estrogenic effluents demonstrates that roach populations living in some effluent-contaminated river stretches, where feminization is widespread, are self-sustaining.
Journal ArticleDOI
The Consequences of Feminization in Breeding Groups of Wild Fish
Catherine A. Harris,Patrick B. Hamilton,Tamsin J. Runnalls,Veronica Vinciotti,Alan Henshaw,Dave J. Hodgson,Tobias S. Coe,Susan Jobling,Charles R. Tyler,John P. Sumpter +9 more
TL;DR: Feminization of male fish is likely to be an important determinant of reproductive performance in rivers where there is a high prevalence of moderately to severely feminized males, demonstrating a significant adverse effect of intersex on reproductive performance.
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Trypanosomes are monophyletic: evidence from genes for glyceraldehyde phosphate dehydrogenase and small subunit ribosomal RNA.
TL;DR: The gGAPDH results support the hypothesis that trypanosomes evolved from an ancestral insect parasite, which adapted to a vertebrate/insect transmission cycle, and implies that the switch from terrestrial insect to aquatic leech vectors for fish and some amphibian try panosomes was secondary.
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Patterns of co-evolution between trypanosomes and their hosts deduced from ribosomal RNA and protein-coding gene phylogenies.
TL;DR: Relationships between trypanosomes are examined using phylogenies based on the genes for the small subunit ribosomal RNA (SSU rRNA) and the glycosomal glyceraldehyde phosphate dehydrogenase (gGAPDH) to resolve the deepest split within the genus.