P
Patrick E. Duffy
Researcher at National Institutes of Health
Publications - 284
Citations - 12320
Patrick E. Duffy is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Malaria & Plasmodium falciparum. The author has an hindex of 54, co-authored 251 publications receiving 10738 citations. Previous affiliations of Patrick E. Duffy include University of Washington & United States Department of the Army.
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Journal ArticleDOI
Adherence of Plasmodium falciparum to Chondroitin Sulfate A in the Human Placenta
Michal Fried,Patrick E. Duffy +1 more
TL;DR: Placental IRBCs adhered to sections of fresh-frozen human placenta with an anatomic distribution similar to that of naturally infected placentas, and adhesion to CSA appears to select for a subpopulation of parasites that causes maternal malaria.
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Malaria: progress, perils, and prospects for eradication
Brian Greenwood,David A. Fidock,Dennis E. Kyle,Stefan H. I. Kappe,Pedro L. Alonso,Frank H. Collins,Patrick E. Duffy +6 more
TL;DR: Insights into parasite biology, human immunity, and vector behavior will guide efforts to translate parasite and mosquito genome sequences into novel interventions, including drugs, vaccines, and insecticides.
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Maternal antibodies block malaria.
Michal Fried,François Nosten,François Nosten,Alan Brockman,Alan Brockman,Bernard J. Brabin,Patrick E. Duffy +6 more
TL;DR: It is shown that anti-adhesion antibodies, which limit the accumulation of parasites in the placenta, appear in pregnant women from Africa and Asia who have been pregnant on previous occasions, but not in those who are pregnant for the first time (primigravidas), and that an anti- adhesion vaccine for maternal malaria may be globally effective.
Journal ArticleDOI
Malaria in pregnancy: pathogenesis and immunity.
Stephen J. Rogerson,Lars Hviid,Lars Hviid,Patrick E. Duffy,Patrick E. Duffy,Rose F. G. Leke,Diane Wallace Taylor,Diane Wallace Taylor +7 more
TL;DR: Understanding of placental immunopathology and how this contributes to anaemia and low birthweight remains restricted, although inflammatory cytokines produced by T cells, macrophages, and other cells are clearly important.
Journal Article
Malaria elicits type 1 cytokines in the human placenta: IFN-gamma and TNF-alpha associated with pregnancy outcomes.
TL;DR: It is concluded that maternal malaria decreases IL-10 concentrations and elicits IFN-gamma, IL-2, and TNF-alpha in the placenta, shifting the balance toward type 1 cytokines, the first demonstration that these placental cytokine changes are associated with poor pregnancy outcomes in humans.