D
Dennis E. Kyle
Researcher at University of Georgia
Publications - 266
Citations - 15155
Dennis E. Kyle is an academic researcher from University of Georgia. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 63, co-authored 249 publications receiving 13945 citations. Previous affiliations of Dennis E. Kyle include Walter Reed Army Institute of Research & QIMR Berghofer Medical Research Institute.
Papers
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Journal ArticleDOI
Malaria: progress, perils, and prospects for eradication
Brian Greenwood,David A. Fidock,Dennis E. Kyle,Stefan H. I. Kappe,Pedro L. Alonso,Frank H. Collins,Patrick E. Duffy +6 more
TL;DR: Insights into parasite biology, human immunity, and vector behavior will guide efforts to translate parasite and mosquito genome sequences into novel interventions, including drugs, vaccines, and insecticides.
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Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum.
Simon J. Foote,Dennis E. Kyle,R. K. Martin,A. M. J. Oduola,K. Forsyth,David J. Kemp,Alan F. Cowman +6 more
TL;DR: It is concluded that a mutated pfmdr1 gene is one of at least two mutated genes required for CQR, and the CQS/CQR status of a further 34 out of 36 isolates is correctly predicted.
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Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance
Donald J. Krogstad,Ilya Y. Gluzman,Dennis E. Kyle,Ayoade M.J. Oduola,Samuel K. Martin,Wilbur K. Milhous,Paul H. Schlesinger +6 more
TL;DR: Verapamil and two other calcium channel blockers, as well as vinblastine and daunomycin, each slowed the release and increased the accumulation of chloroquine by resistant (but not susceptible) Plasmodium falciparum.
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Evidence for the shikimate pathway in apicomplexan parasites
Fiona Roberts,Fiona Roberts,Craig W. Roberts,Jennifer J. Johnson,Dennis E. Kyle,Tino Krell,John R. Coggins,Graham H. Coombs,Wilbur K. Milhous,Saul Tzipori,David J. P. Ferguson,Debopam Chakrabarti,Rima McLeod +12 more
TL;DR: The shikimate pathway is an attractive target for herbicides and antimicrobial agents because it is essential in algae, higher plants, bacteria and fungi, but absent from mammals as discussed by the authors.
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Clinical Studies of Atovaquone, Alone or in Combination with other Antimalarial Drugs, for Treatment of Acute Uncomplicated Malaria in Thailand
Sornchai Looareesuwan,Chaisin Viravan,H. K. Webster,Dennis E. Kyle,David B. A. Hutchinson,Craig J. Canfield +5 more
TL;DR: Of the 104 patients with falciparum malaria treated with atovaquone plus proguanil for 3-7 days, 101 were cured and had virtually no adverse side effects, but parasitemia recurred in most patients.