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Patrick J. Drew
Researcher at Pennsylvania State University
Publications - 70
Citations - 5015
Patrick J. Drew is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Cerebral blood flow & Medicine. The author has an hindex of 30, co-authored 65 publications receiving 3908 citations. Previous affiliations of Patrick J. Drew include University of California, San Diego & California Institute of Technology.
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Journal ArticleDOI
Cascade models of synaptically stored memories.
TL;DR: It is suggested that memory storage requires synapses with multiple states exhibiting dynamics over a wide range of timescales, and the model constructed here combines high levels of memory storage with long retention times and significantly outperforms alternative models.
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Correlations of neuronal and microvascular densities in murine cortex revealed by direct counting and colocalization of nuclei and vessels.
Philbert S. Tsai,John Patrick Kaufhold,Pablo Blinder,Beth Friedman,Patrick J. Drew,Harvey J. Karten,Patrick D. Lyden,David Kleinfeld +7 more
TL;DR: In this article, the locations of all neuronal and non-neuronal nuclei and the centerlines and diameters of all blood vessels within thick slabs of neocortex from mice were mapped using histological, imaging, and analysis tools.
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Two-Photon Microscopy as a Tool to Study Blood Flow and Neurovascular Coupling in the Rodent Brain
Andy Y. Shih,Jonathan D. Driscoll,Patrick J. Drew,Nozomi Nishimura,Chris B. Schaffer,David Kleinfeld +5 more
TL;DR: The surgical procedures required to generate cranial windows for optical access to the cortex of both rats and mice and the use of two-photon microscopy to accurately measure blood flow in individual cortical vessels concurrent with local cellular activity are described.
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Chronic optical access through a polished and reinforced thinned skull
Patrick J. Drew,Andy Y. Shih,Jonathan D. Driscoll,Per Magne Knutsen,Pablo Blinder,Dimitrios Davalos,Katerina Akassoglou,Philbert S. Tsai,David Kleinfeld +8 more
TL;DR: This work presents a method to form an optical window in the mouse skull that spans millimeters and is stable for months without causing brain inflammation, which enabled them to repeatedly image blood flow in cortical capillaries of awake mice and determine long-range correlations in speed.
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Fluctuating and sensory-induced vasodynamics in rodent cortex extend arteriole capacity
TL;DR: It is concluded that stimulation that occurs on the time scale of natural stimuli leads to a net increase in the reservoir of arteriole blood, and a “bagpipe” model that highlights arterioles dilation should augment the current “balloon’ model of venous distension in the interpretation of fMRI images.