D
Dimitrios Davalos
Researcher at Cleveland Clinic Lerner Research Institute
Publications - 33
Citations - 6855
Dimitrios Davalos is an academic researcher from Cleveland Clinic Lerner Research Institute. The author has contributed to research in topics: Microglia & Inflammation. The author has an hindex of 19, co-authored 30 publications receiving 5519 citations. Previous affiliations of Dimitrios Davalos include Gladstone Institutes & University of California, San Diego.
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Journal ArticleDOI
ATP mediates rapid microglial response to local brain injury in vivo
Dimitrios Davalos,Jaime Grutzendler,Jaime Grutzendler,Guang Yang,Jiyun Kim,Yi Zuo,Steffen Jung,Dan R. Littman,Michael L. Dustin,Wen-Biao Gan +9 more
TL;DR: Extracellular ATP regulates microglial branch dynamics in the intact brain, and its release from the damaged tissue and surrounding astrocytes mediates a rapid microglia response towards injury.
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Fibrinogen as a key regulator of inflammation in disease
TL;DR: The role of fibrinogen in inflammatory disease is focused on highlighting its unique structural properties, cellular targets, and signal transduction pathways that make it a potent proinflammatory mediator and a potential therapeutic target.
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Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation
Dimitrios Davalos,Jae K. Ryu,Mario Merlini,Kim M. Baeten,Natacha Le Moan,Mark A. Petersen,Thomas J. Deerinck,Dimitri S. Smirnoff,Catherine Bedard,Hiroyuki Hakozaki,Sara G. Murray,Jennie B. Ling,Hans Lassmann,Jay L. Degen,Mark H. Ellisman,Katerina Akassoglou +15 more
TL;DR: It is demonstrated that microglia form perivascular clusters before myelin loss or paralysis onset and that, of the plasma proteins, fibrinogen specifically induces rapid and sustained microglial responses in vivo.
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Chronic optical access through a polished and reinforced thinned skull
Patrick J. Drew,Andy Y. Shih,Jonathan D. Driscoll,Per Magne Knutsen,Pablo Blinder,Dimitrios Davalos,Katerina Akassoglou,Philbert S. Tsai,David Kleinfeld +8 more
TL;DR: This work presents a method to form an optical window in the mouse skull that spans millimeters and is stable for months without causing brain inflammation, which enabled them to repeatedly image blood flow in cortical capillaries of awake mice and determine long-range correlations in speed.
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Oligodendrocyte precursors migrate along vasculature in the developing nervous system
Hui-Hsin Tsai,Jianqin Niu,Roeben N. Munji,Dimitrios Davalos,Junlei Chang,Haijing Zhang,An-Chi Tien,Calvin J. Kuo,Jonah R. Chan,Richard Daneman,Stephen P.J. Fancy +10 more
TL;DR: It is shown that OPCs of the embryonic mouse brain and spinal cord, as well as the human cortex, emerge from progenitor domains and associate with the abluminal endothelial surface of nearby blood vessels, and it is proposed that this signaling coordinates OPC migration with differentiation.