N
Nozomi Nishimura
Researcher at Cornell University
Publications - 130
Citations - 6107
Nozomi Nishimura is an academic researcher from Cornell University. The author has contributed to research in topics: Cerebral blood flow & Blood flow. The author has an hindex of 31, co-authored 116 publications receiving 4982 citations. Previous affiliations of Nozomi Nishimura include Harvard University & University of California.
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Journal ArticleDOI
Deep tissue multiphoton microscopy using longer wavelength excitation.
TL;DR: The maximal two-photon fluorescence microscopy (TPM) imaging depth achieved with 775-nm excitation is compared to that achieved with 1280- nm excitation through in vivo and ex vivo TPM of fluorescently-labeled blood vessels in mouse brain.
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Two-Photon Microscopy as a Tool to Study Blood Flow and Neurovascular Coupling in the Rodent Brain
Andy Y. Shih,Jonathan D. Driscoll,Patrick J. Drew,Nozomi Nishimura,Chris B. Schaffer,David Kleinfeld +5 more
TL;DR: The surgical procedures required to generate cranial windows for optical access to the cortex of both rats and mice and the use of two-photon microscopy to accurately measure blood flow in individual cortical vessels concurrent with local cellular activity are described.
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Two-photon imaging of cortical surface microvessels reveals a robust redistribution in blood flow after vascular occlusion.
Chris B. Schaffer,Beth Friedman,Beth Friedman,Nozomi Nishimura,Lee F. Schroeder,Philbert S. Tsai,Ford F. Ebner,Patrick D. Lyden,Patrick D. Lyden,David Kleinfeld +9 more
TL;DR: The cortical arteriolar network supports collateral flow that may mitigate the effects of vessel obstruction, as may occur secondary to neurovascular pathology, when blood is redistributed after vascular occlusion.
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In vivo three-photon imaging of activity of GCaMP6-labeled neurons deep in intact mouse brain
Dimitre G. Ouzounov,Tianyu Wang,Mengran Wang,Danielle Feng,Nicholas G. Horton,Jean C. Cruz-Hernandez,Yu-Ting Cheng,Jacob Reimer,Andreas S. Tolias,Andreas S. Tolias,Nozomi Nishimura,Chris Xu +11 more
TL;DR: This work demonstrates that three-photon microscopy at 1,300-nm excitation enables functional imaging of GCaMP6s-labeled neurons beyond the depth limit of two-ph photon microscopy, and creates opportunities for noninvasive recording of neuronal activity with high spatial and temporal resolution deep within scattering brain tissues.
Journal ArticleDOI
Suppressed Neuronal Activity and Concurrent Arteriolar Vasoconstriction May Explain Negative Blood Oxygenation Level-Dependent Signal
Anna Devor,Peifang Tian,Nozomi Nishimura,Ivan C. Teng,Elizabeth M. C. Hillman,Suresh N. Narayanan,István Ulbert,David A. Boas,David Kleinfeld,Anders M. Dale +9 more
TL;DR: In this article, the authors used a suite of in vivo imaging tools to study neurovascular coupling in rat primary somatosensory cortex and found that the response was composed of a combination of dilatory and constrictive phases.