P
Patrick J.H. de Koning
Researcher at Leiden University Medical Center
Publications - 33
Citations - 1129
Patrick J.H. de Koning is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Magnetic resonance angiography & Medicine. The author has an hindex of 14, co-authored 29 publications receiving 938 citations. Previous affiliations of Patrick J.H. de Koning include Leiden University & Johns Hopkins University.
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Journal ArticleDOI
Magnetic resonance angiography of intracranial and extracranial arteries in patients with spontaneous migraine without aura: a cross-sectional study
Faisal Mohammad Amin,Mohammad Sohail Asghar,Anders Hougaard,Adam E. Hansen,Vibeke Andrée Larsen,Patrick J.H. de Koning,Henrik Larsson,Jes Olesen,Messoud Ashina +8 more
TL;DR: Migraine pain was not accompanied by extracranial arterial dilatation, and by only slight intracranial dilated arteries, and future migraine research should focus on the peripheral and central pain pathways rather than simple arterial Dilatation.
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Investigation of the pathophysiological mechanisms of migraine attacks induced by pituitary adenylate cyclase-activating polypeptide-38
Faisal Mohammad Amin,Anders Hougaard,Henrik Winther Schytz,Mohammad Sohail Asghar,Elisabet Lundholm,Arushma I. Parvaiz,Patrick J.H. de Koning,Malene R. Andersen,Henrik Larsson,Jan Fahrenkrug,Jes Olesen,Messoud Ashina +11 more
TL;DR: PACAP38 has a much higher affinity for thePAC1 receptor and it is suggested that migraine induction by PACAP38 may be because of activation of the PAC1 receptor, which may be a future anti-migraine drug target.
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Headache and prolonged dilatation of the middle meningeal artery by PACAP38 in healthy volunteers
Faisal Mohammad Amin,Mohammad Sohail Asghar,Song Guo,Anders Hougaard,Adam E. Hansen,Henrik Winther Schytz,Rob J. van der Geest,Patrick J.H. de Koning,Henrik Larsson,Jes Olesen,Messoud Ashina +10 more
TL;DR: Sumatriptan relieves headache in parallel with contraction of the MMA but not of the MCA, as found in a double-blind, randomized, placebo-controlled study.
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Migraine induced by hypoxia: an MRI spectroscopy and angiography study.
Nanna Arngrim,Henrik Winther Schytz,Josefine Britze,Faisal Mohammad Amin,Mark B Vestergaard,Anders Hougaard,Frauke Wolfram,Patrick J.H. de Koning,Karsten Skovgaard Olsen,Niels H. Secher,Henrik Larsson,Jes Olesen,Messoud Ashina +12 more
TL;DR: Hypoxia induced migraine-like attacks with and without aura and dilated the cranial arteries in patients with migraine with aura, and hypoxia-induced attacks were not associated with altered concentration of glutamate or other metabolites.
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Energetics of Blood Flow in Cardiovascular Disease: Concept and Clinical Implications of Adverse Energetics in Patients With a Fontan Circulation.
Friso M Rijnberg,Mark G. Hazekamp,Jolanda J. Wentzel,Patrick J.H. de Koning,Jos J.M. Westenberg,Monique R.M. Jongbloed,Nico A. Blom,Arno A.W. Roest +7 more
TL;DR: The theoretical background of mechanical energy of blood flow in the cardiovascular system and the methods of calculating energy loss are described, and an overview of geometric factors associated with energy efficiency in the TCPC and its implications on clinical outcome are given.