P
Patrick Mailliet
Researcher at Aventis Pharma
Publications - 34
Citations - 2004
Patrick Mailliet is an academic researcher from Aventis Pharma. The author has contributed to research in topics: Telomere & Telomerase. The author has an hindex of 17, co-authored 34 publications receiving 1931 citations. Previous affiliations of Patrick Mailliet include University of Reims Champagne-Ardenne & French Institute of Health and Medical Research.
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Journal ArticleDOI
Natural and pharmacological regulation of telomerase
Jean-Louis Mergny,Jean-François Riou,Patrick Mailliet,Marie-Paule Teulade-Fichou,Eric Gilson +4 more
TL;DR: Telomeres and telomerase may be proposed as attractive targets for the discovery of new anticancer agents because of their specialised structures when it comes to replicating the DNA.
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Preferential binding of a G-quadruplex ligand to human chromosome ends
Christine Granotier,Gaëlle Pennarun,Lydia Riou,Françoise Hoffschir,Laurent Gauthier,Anne De Cian,Dennis Gomez,Eliane Mandine,Jean-François Riou,Jean-Louis Mergny,Patrick Mailliet,Bernard Dutrillaux,François D. Boussin +12 more
TL;DR: The results provide evidence that a specific G-quadruplex ligand interacts with the terminal ends of human chromosomes and support the hypothesis that G- Quadruple ligands induce and/or stabilize G- quadruplex structures at telomeres of human cells.
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Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands.
Gaëlle Pennarun,Christine Granotier,Laurent Gauthier,Dennis Gomez,Françoise Hoffschir,Eliane Mandine,Jean-François Riou,Jean-Louis Mergny,Patrick Mailliet,François D. Boussin +9 more
TL;DR: Pyridine-based G-quadruplex ligands are promising agents for the treatment of various tumors including malignant gliomas, and it is shown that apoptosis was preceded by multiple alterations of the cell cycle: activation of S-phase checkpoints, dramatic increase of metaphase duration and cytokinesis defects.
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Telomerase downregulation induced by the G‐quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing
Dennis Gomez,Thibault Lemarteleur,Laurent Lacroix,Patrick Mailliet,Jean-Louis Mergny,Jean-François Riou +5 more
TL;DR: It is proposed that 12459 impairs the splicing machinery of hTERT through stabilization of quadruplexes located in the h TERT intron 6, and is able to stabilize the formation of these G-quadruplex structures.
Journal ArticleDOI
Ethidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexes
Florence Koeppel,Jean-François Riou,Abdelazize Laoui,Patrick Mailliet,Paola B. Arimondo,Delphine Labit,Odile Petitgenet,Claude Hélène,Jean-Louis Mergny +8 more
TL;DR: Ethidium derivatives that stabilize G-quadruplexes are described, which showed a potent anti-telomerase activity in vitro, and may be used to reveal the formation of multi-stranded DNA structures by standard fluorescence imaging, and therefore become fluorescent probes of quadruplex structures.