P
Patrick Meraldi
Researcher at University of Geneva
Publications - 76
Citations - 7271
Patrick Meraldi is an academic researcher from University of Geneva. The author has contributed to research in topics: Mitosis & Kinetochore. The author has an hindex of 36, co-authored 71 publications receiving 6808 citations. Previous affiliations of Patrick Meraldi include Innsbruck Medical University & École Polytechnique Fédérale de Lausanne.
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Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53−/− cells
TL;DR: It is proposed that errors during cell division, combined with the inability to detect the resulting hyperploidy, constitute a major cause for numerical centrosome aberrations in tumors.
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Human TPX2 is required for targeting Aurora-A kinase to the spindle
Thomas A. Kufer,Herman H W Silljé,Roman Körner,Oliver J. Gruss,Patrick Meraldi,Erich A. Nigg +5 more
TL;DR: Aurora-A is a serine-threonine kinase implicated in the assembly and maintenance of the mitotic spindle as mentioned in this paper, and it is shown that Aurora-A binds to TPX2, a prominent component of the spindle apparatus.
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Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A.
TL;DR: It is shown that centrosome duplication requires the activation of E2F transcription factors and Cdk2–cyclin A activity, which is a key requirement for bipolar spindle formation and correct segregation of chromosomes during cell division.
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Timing and Checkpoints in the Regulation of Mitotic Progression
TL;DR: It is proposed that cytosolic Mad2-BubR1 is essential to restrain anaphase onset early in mitosis when kinetochores are still assembling, and whereas checkpoint control requires kinetchores, the regulation of mitotic timing by Mad2 and BubR 1 is kinet Cochore-independent in fashion.
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C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2.
Andrew M. Fry,Thibault Mayor,Patrick Meraldi,York-Dieter Stierhof,Kayoko Tanaka,Erich A. Nigg +5 more
TL;DR: The molecular characterization of a novel human centrosomal protein, C-Nap1, first identified as a Nek2-interacting protein in a yeast two-hybrid screen is described and a model implicating both Nek2 and C- Napoleon in the regulation of centriole–centriole cohesion during the cell cycle is proposed.