P
Patrick Wong
Researcher at National Institutes of Health
Publications - 2
Citations - 245
Patrick Wong is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Somatic hypermutation & Viral replication. The author has an hindex of 2, co-authored 2 publications receiving 216 citations. Previous affiliations of Patrick Wong include Vaccine Research Center.
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Journal ArticleDOI
HIV-1 fitness cost associated with escape from the VRC01 class of CD4 binding site neutralizing antibodies
Rebecca M. Lynch,Patrick Wong,Lillian Tran,Sijy O'Dell,Martha Nason,Yuxing Li,Xueling Wu,John R. Mascola +7 more
TL;DR: It is shown that escape from VRC01 class antibodies can be associated with impaired viral entry and replication; however, during the course of natural infection, compensatory mutations restore the ability of the virus to replicate normally.
Journal ArticleDOI
Quality and quantity of TFH cells are critical for broad antibody development in SHIVAD8 infection.
Takuya Yamamoto,Rebecca M. Lynch,Rajeev Gautam,Rodrigo Matus-Nicodemos,Stephen D. Schmidt,Kristin L. Boswell,Sam Darko,Patrick Wong,Zizhang Sheng,Constantinos Petrovas,Adrian B. McDermott,Robert A. Seder,Brandon F. Keele,Lawrence Shapiro,Daniel C. Douek,Yoshiaki Nishimura,John R. Mascola,Malcolm A. Martin,Richard A. Koup +18 more
TL;DR: Findings suggest that HIV vaccines that incorporate TFH cell stimulation may boost broadly neutralizing antibody production, and highlight the importance of boosting high-quality TFH populations as part of a robust vaccine regimen aimed at eliciting bNabs.