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Xueling Wu
Researcher at Aaron Diamond AIDS Research Center
Publications - 68
Citations - 8718
Xueling Wu is an academic researcher from Aaron Diamond AIDS Research Center. The author has contributed to research in topics: Antibody & Epitope. The author has an hindex of 37, co-authored 61 publications receiving 7975 citations. Previous affiliations of Xueling Wu include Vaccine Research Center & University of Alabama at Birmingham.
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Journal ArticleDOI
Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1
Xueling Wu,Zhi Yong Yang,Yuxing Li,Carl Magnus Hogerkorp,William R. Schief,Michael S. Seaman,Tongqing Zhou,Stephen D. Schmidt,Lan Wu,Ling Xu,Nancy S. Longo,Krisha McKee,Sijy O'Dell,Mark K. Louder,Diane Wycuff,Yu Feng,Martha Nason,Nicole A. Doria-Rose,Mark Connors,Peter D. Kwong,Mario Roederer,Richard T. Wyatt,Gary J. Nabel,John R. Mascola +23 more
TL;DR: Three broadly neutralizing antibodies are identified, isolated from an HIV-1–infected individual, that exhibited great breadth and potency of neutralization and were specific for the co-receptor CD4-binding site of the glycoprotein 120 (gp120), part of the viral Env spike.
Journal ArticleDOI
Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01.
Tongqing Zhou,Ivelin S. Georgiev,Xueling Wu,Zhi Yong Yang,Kaifan Dai,Andrés Finzi,Young Do Kwon,Johannes F. Scheid,Wei Shi,Ling Xu,Yongping Yang,Jiang Zhu,Michel C. Nussenzweig,Joseph Sodroski,Lawrence Shapiro,Lawrence Shapiro,Gary J. Nabel,John R. Mascola,Peter D. Kwong +18 more
TL;DR: The identification of three broadly neutralizing antibodies, isolated from an HIV-1–infected individual, that exhibited great breadth and potency of neutralization and were specific for the co-receptor CD4-binding site of the glycoprotein 120 (gp120), part of the viral Env spike.
Journal ArticleDOI
Broad HIV-1 neutralization mediated by CD4-binding site antibodies
Yuxing Li,Stephen A. Migueles,Brent Welcher,Krisha Svehla,Adhuna Phogat,Mark K. Louder,Xueling Wu,George M. Shaw,Mark Connors,Richard T. Wyatt,John R. Mascola +10 more
TL;DR: Using antibody adsorption and elution from selected gp120 variants, the neutralizing specificities of the two most broadly reactive sera were mapped to the primary receptor CD4–binding region of HIV-1 gp120.
Journal ArticleDOI
Human Immunodeficiency Virus Type 1 V1-V2 Envelope Loop Sequences Expand and Add Glycosylation Sites over the Course of Infection, and These Modifications Affect Antibody Neutralization Sensitivity
TL;DR: It is suggested that changes within the V1-V2 envelope domains over the course of an infection influence sensitivity to autologous neutralizing antibodies and may also impact host receptor/coreceptor interactions.
Journal ArticleDOI
Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120.
Lei Chen,Young Do Kwon,Tongqing Zhou,Xueling Wu,Sijy O'Dell,Lisa A. Cavacini,Ann J. Hessell,Marie Pancera,Min Tang,Ling Xu,Zhi Yong Yang,Mei-Yun Zhang,James Arthos,Dennis R. Burton,Dennis R. Burton,Dimiter S. Dimitrov,Gary J. Nabel,Marshall R. Posner,Joseph Sodroski,Richard T. Wyatt,John R. Mascola,Peter D. Kwong +21 more
TL;DR: Co-crystal structures for two poorly neutralizing, CD4–binding site (CD4BS) antibodies, F105 and b13, in complexes with gp120 are determined, finding these conformations to be poorly compatible with the viral spike.