Patrizia Galletti

TL;DR: The results suggest that hyperhomocysteinaemia affects epigenetic control of gene expression, which can be reverted by folate treatment, and the hypothesis that the toxic action of homocysteine can be mediated by macromolecule hypomethylation is supported.

TL;DR: Dietary intake of olive oil polyphenols may lower the risk of reactive oxygen metabolite-mediated diseases such as some gastrointestinal diseases and atherosclerosis, and the data demonstrate that (3,4-dihydroxyphenyl)ethanol can act as a biological antioxidant in a cell culture experimental model.

TL;DR: It is demonstrated that resveratrol causes a complete and reversible cell cycle arrest at the S phase checkpoint, indicating that the G1 --> S transition occurs normally.

TL;DR: The pharmacokinetic analysis indicates a fast and extensive uptake of the molecule by the organs and tissues investigated, with a preferential renal uptake, and an intracellular metabolic pathway of exogenously administered DOPET, implying the involvement of catechol-O-methyltransferase, alcohol dehydrogenase, aldehyde dehydrogen enzyme, and phenolsulfotransferase has been proposed.

TL;DR: The kinetic data demonstrate that [14C]DPE transport occurs via a passive diffusion mechanism and is bidirectional; the calculated apparent permeability coefficient indicates that the molecule is quantitatively absorbed at the intestinal level.