Patrizio Odetti

TL;DR: It is shown that alternating PF and nutrient-rich medium extended yeast lifespan independently of established pro-longevity genes and decreased risk factors/biomarkers for aging, diabetes, cardiovascular disease, and cancer without major adverse effects, providing support for the use of FMDs to promote healthspan.

TL;DR: Immunohistochemical localization studies revealed that pyrraline is found predominantly in the sclerosed extracellular matrix of glomerular and arteriolar renal tissues from both diabetic and aged nondiabetic individuals, suggesting that molecular damage by advanced Maillard reaction products may be a common mechanism in their development.

TL;DR: A high correlation betweenpentosidine levels and long-wave collagen-linked fluorescence also was observed, suggesting that pentosidine is a generalized marker of accelerated tissue modification by the advanced glycosylation/Maillard reaction, which is enhanced in IDDM patients with severe complications.

TL;DR: Plasma pentosidine may be a useful marker for monitoring the biochemical efficacy of trials with aminoguanidine or other treatment modalities and may act as a signal for advanced glycosylation end product-mediated receptor uptake by macrophages and other cells and contribute to accelerated atherosclerosis in diabetes and uremia.

TL;DR: It is demonstrated that pentosidine increases exponentially in cortical bone during aging, and is thus a good biomarker for the degree of bone mass density loss.