R
Ramanakoppa H. Nagaraj
Researcher at Case Western Reserve University
Publications - 29
Citations - 2475
Ramanakoppa H. Nagaraj is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Maillard reaction & Methylglyoxal. The author has an hindex of 22, co-authored 29 publications receiving 2416 citations. Previous affiliations of Ramanakoppa H. Nagaraj include University Hospitals of Cleveland.
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Journal ArticleDOI
Maillard reaction-mediated molecular damage to extracellular matrix and other tissue proteins in diabetes, aging, and uremia.
Vincent M. Monnier,David R. Sell,Ramanakoppa H. Nagaraj,Satoshi Miyata,Sunitha K. Grandhee,Patrizio Odetti,Said A Ibrahim +6 more
TL;DR: Immunohistochemical localization studies revealed that pyrraline is found predominantly in the sclerosed extracellular matrix of glomerular and arteriolar renal tissues from both diabetic and aged nondiabetic individuals, suggesting that molecular damage by advanced Maillard reaction products may be a common mechanism in their development.
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Protein Cross-linking by the Maillard Reaction ISOLATION, CHARACTERIZATION, AND IN VIVO DETECTION OF A LYSINE-LYSINE CROSS-LINK DERIVED FROM METHYLGLYOXAL
TL;DR: Results provide chemical evidence for protein cross-linking by dicarbonyl compounds in vivo and name this cross-link imidazolysine, detected in proteins by high performance liquid chromatography using a postcolumn derivatization method.
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Protein Modification by Methylglyoxal: Chemical Nature and Synthetic Mechanism of a Major Fluorescent Adduct
TL;DR: It is indicated that argpyrimidine is synthesized through an intermediate 3-hydroxypentane-2,4-dione and provide a chemical basis for fluorescence in proteins modified by methylglyoxal, suggesting that it is a major product in such modified proteins.
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High correlation between pentosidine protein crosslinks and pigmentation implicates ascorbate oxidation in human lens senescence and cataractogenesis
Ramanakoppa H. Nagaraj,David R. Sell,Malladi Prabhakaram,Beryl J. Ortwerth,Vincent M. Monnier +4 more
TL;DR: The results suggest that redox imbalance in cellular senescent systems such as the ocular lens may lead to irreversible ascorbate oxidation and protein crosslinking by xylosone, which may play an important role in the pathogenesis of "brunescent" cataracts.
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Protein Crosslinking by the Maillard Reaction: Dicarbonyl-Derived Imidazolium Crosslinks in Aging and Diabetes
TL;DR: An HPLC method can be used for quantification of imidazolium crosslinks in tissue proteins to assess alpha-dicarbonyl-mediated protein damage in vivo and is significant in terms of tissue damage in aging and diabetes.