Pau Pascual-Garcia

TL;DR: It is demonstrated that Sus1 is involved in the SAGA-dependent histone H2B deubiquitinylation and maintenance of normal H3 methylation levels and the Sus1-Sgf11-Ubp8 module could work at the junction between SAGa-dependent transcription and nuclear mRNA export.

TL;DR: The presence of multiple Nups at promoters, enhancers, and insulators in the Drosophila genome is identified and a functional role for Nup98 is uncovered in mediating enhancer-promoter looping at ecdysone-inducible genes.

TL;DR: It is shown that Sus1 is required during transcription elongation and is associated with the elongating form of RNA Polymerase II (RNAP II) phosphorylated on Ser5 and Ser2 of the C-terminal domain (CTD), and that Sgf73 is necessary for association of Sus1 with both SAGA and TREX2, and that its absence dramatically reduces Sus1 occupancy of UAS and ORF sequences.

TL;DR: Roles of Nup98 in epigenetic regulation that may underlie the basis of oncogenicity of N up98 fusions in leukemia are introduced.

TL;DR: This investigation uncovered differential binding of these NPC subunits, where Nup107 preferentially targets active genes while Nup93 associates primarily with Polycomb-silenced regions, and lend to a model where different nuclear pores bind different types of chromatin via interactions with specific NPC sub-complexes, and a subset of Polycomb domains is stabilized by interactions with N up93.