Showing papers in "Journal of Laboratory and Clinical Medicine in 1993"

TL;DR: It is suggested that the protective effect of aspirin and other NSAIDs in the development of human colon cancer may be mediated, at least in part, through their inhibition of arachidonic acid metabolism by cyclooxygenase.

TL;DR: It seems that -SH groups are a major target of attack by HOCI/OCI- in vivo, and plasma albumin may be an important protective antioxidant.

TL;DR: It is concluded that the DCLHb-induced elevation of MAP in vivo is mediated at least in part by ET and the inhibition of NO, the first report of the pressor response to hemoglobin being attenuated by an agent that blocks the conversion of proendothelin to ET.

TL;DR: Low concentrations of defensin in the plasma of healthy volunteers and patients with sepsis and meningitis may reflect neutrophil activation at sites of infection and inflammation, and studies of the clinical utility ofdefensin ELISA are indicated.

TL;DR: It is indicated that apolipoprotein E polymorphism of most Japanese people can be determined by analyzing the apo E genome between bases 2849 and 3071.

TL;DR: In this paper, the authors explore the role of locally synthesized transforming growth factor beta-1 (TGF-beta 1) and procollagen gene expression in postburn hypertrophic scars.

TL;DR: Observations indicate that POMC products may accumulate locally in lesional skin representing, presumably, a novel cutaneous response to injury.

TL;DR: The results suggest that increased pancreatic lysosomal fragility observed with ethanol may be mediated by fatty acid ethyl esters.

TL;DR: It is found that immunoglobulin G (IgG) does spontaneously adsorb to polymer surfaces, both in vitro and in vivo, and spontaneously-adsorbed surface IgG does not appear to be a necessary precedent to inflammatory responses directed against implanted biomaterials.

TL;DR: Experimental models that simulate primary and secondary hyperaldosteronism, each of which are associated with the appearance of myocardial fibrosis, tested the hypothesis that such tissue ACE is related to fibrous tissue formation and that its appearance is independent of circulating renin and angiotensin peptides.

TL;DR: Analysis of variance for repeated measurements revealed that changes in the clearance of beta 2-microglobulin were related to those in IL-6 and marginally also to TNF-alpha in dialysate and more closely related to alterations in Dialysate PGE2.

TL;DR: Comparisons of the proteasome levels in normal subjects and patients with benign liver diseases suggest that the elevated levels of serum proteasomes in these patients are derived from tumor cells, reflect the tumor burden, and so provide prognostic information.

TL;DR: The data indicate that nitric oxide synthase inhibitors attenuate chemotaxis of unstimulated and primed polymorphonuclear leukocytes in vitro, suggesting that the L-arginine/nitric oxide biosynthetic pathway plays an important role in regulating polymorphonnuclear leukocyte emigration in vivo.

TL;DR: Increased endothelin-1 messenger RNA in glomeruli may be a manifestation of diabetic nephropathy, and hyperglycemia or insulin-deficiency may play a role in abnormal endothelins-1 gene regulation.

TL;DR: Investigation of human cysteinyl-leukotriene metabolism in vitro, ex vivo, and in vivo in the absence and presence of dietary n-3 fatty acids demonstrates formation of leukotrienes C5, D5, and E5 from eicosapentaenoic acid in vitro and ex vivo in stimulated human granulocytes.

TL;DR: The hypothesis that heparin and other GAGs may exert an antiinflammatory role is supported, as coincubation of platelets with fMLP-stimulated PMN resulted in platelet activation, a process mainly mediated by the PMN-derived serine protease cathepsin G.

TL;DR: It was found that elastase activity in BAL correlated significantly with the ratio of forced expiratory volume in 1 second to forced vital capacity (FEV1/FVC ratio) and FEV1 percent predicted, and the degree of airflow obstruction, NE activity, myeloperoxidase activity, or total neutrophils in BAL did not correlate with the density of P. aeruginosa in BAL.

TL;DR: First in vivo evidence that supports the concept that release of vasoactive mediators in hereditary angiodema attacks is associated with the activation of the fibrinolytic system is presented.

TL;DR: To assess relationships of endogenous testosterone with fibrinolytic activities, lipids, lipoproteins, and coronary heart disease risk factors in 55 newly referred hyperlipidemic men, a stepwise multiple regression study was done.

TL;DR: Altered mechanisms of zinc homeostasis suggest that chronic human zinc deficiency warrants reassessment of dietary zinc requirement to preserve normal zinc status in the subsets of population that are vulnerable to zinc deficiency.

TL;DR: Interstrain variation of membrane rigidity could influence pathophysiology in several ways: by promoting margination and cytoadherence of knob-positive strains in the microcirculation, by modulating clearance of parasitized cells by the reticuloendothelial system, and by influencing ischemic complications of severe falciparum malaria.

TL;DR: Flow cytometry is useful for the detection of changes in the expression of membrane glycoproteins induced by platelet activation in vitro and during platelet storage, and in vivo in patients.

TL;DR: Monitoring of AII and MR binding in the rat heart and kidney after chronic AII or ALDO infusion found no change in receptor or MR binding.

TL;DR: The data indicate that iron overload aggravates anthracycline toxicity and that this interaction may be prevented by effective iron chelating therapy, and the protective effect of DF in iron-loaded cells and its failure to prevent Anthracy Cline toxicity in normal cells were both associated with a significant decrease in MDA measurements.

TL;DR: Observed observations indicating increased lysosomal fragility in iron-loaded hepatic and splenic tissues, attributed to increased membrane lipid peroxidation, imply that iron-induced peroxidative damage to membrane proteins may be a more important mechanism in the pathogenesis of altered myocardial function in the iron- loaded heart than formerly was recognized.

TL;DR: The atopic isoenzyme was found to be consistently more sensitive to a number of phosphodiesterase inhibitors and may affect many pathways of cell regulation and thus could be an important therapeutic target for management of cutaneous and respiratory inflammation.

TL;DR: It is suggested that increased rates of uptake of NTBI may exacerbate iron loading of the heart and contribute to iron-mediated cardiotoxicity, whereas the clinical benefits of chelation therapy may be enhanced by the down-regulation ofNTBI uptake.

TL;DR: Both the typically episodic clinical features and the terminal event in fatal cases of the long QT syndrome may be due to apoptosis, sometimes called programmed cell death.

TL;DR: It is obvious that dietary protein restriction, treatment of systemic and intraglomerular hypertension and lipid abnormalities, and prevention of iron overload, all play roles in the preservation of renal function in CRF.